Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed thatmicroRNAs (miRNAs) are differentially expressed in cortical interneuron subtypes, and are essential for the normalmigration, maturation, and survival of medial ganglionic eminence-derived interneuron subtypes. How miRNAs function invasoactive intestinal peptide expressing (VIP+) interneurons derived from the caudal ganglionic eminence remains elusive.Here, we conditionally removedDicerin postmitotic VIP+interneurons to block miRNA biogenesis. We found that theintrinsic and synaptic properties of VIP+interneurons and pyramidal neurons were concordantly affected prior to aprogressive loss of VIP+interneurons. In vivo recording further revealed elevated cortical local field potential power. Mutantmice had a shorter life span but exhibited better spatial working memory and motor coordination. Our results demonstratethat miRNAs are indispensable for the function and survival of VIP+interneurons, and highlight a key role of VIP+interneurons in cortical circuits.
microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction / Qiu, Fang; Mao, Xingfeng; Liu, Penglai; Wu, Jinyun; Zhang, Yuan; Sun, Daijing; Zhu, Yueyan; Gong, Ling; Shao, Mengmeng; Fan, Keyang; Chen, Junjie; Lu, Jiangteng; Jiang, Yan; Zhang, Yubin; Curia, Giulia; Li, Anan; He, Miao. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - 30:4(2020), pp. 2229-2249. [10.1093/cercor/bhz236]