It has been known that algogens and cooling could inhibit itch sensation; however, the underlying molecular and neural mechanisms remain poorly understood. Here, we show that the spinal neurons expressing gastrin releasing peptide receptor (GRPR) primarily comprise excitatory interneurons that receive direct and indirect inputs from C and Aδ fibers and form contacts with projection neurons expressing the neurokinin 1 receptor (NK1R). Importantly, we show that noxious or cooling agents inhibit the activity of GRPR neurons via GABAergic signaling. By contrast, capsaicin, which evokes a mix of itch and pain sensations, enhances both excitatory and inhibitory spontaneous synaptic transmission onto GRPR neurons. These data strengthen the role of GRPR neurons as a key circuit for itch transmission and illustrate a spinal mechanism whereby pain inhibits itch by suppressing the function of GRPR neurons.

Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord / Bardoni, Rita; Shen, Kai-Feng; Li, Hui; Jeffry, Joseph; Barry, Devin M.; Comitato, Antonella; Li, Yun-Qing; Chen, Zhou-Feng. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019), pp. 15804-15804. [10.1038/s41598-019-52316-0]

Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord

Bardoni, Rita;Comitato, Antonella;
2019

Abstract

It has been known that algogens and cooling could inhibit itch sensation; however, the underlying molecular and neural mechanisms remain poorly understood. Here, we show that the spinal neurons expressing gastrin releasing peptide receptor (GRPR) primarily comprise excitatory interneurons that receive direct and indirect inputs from C and Aδ fibers and form contacts with projection neurons expressing the neurokinin 1 receptor (NK1R). Importantly, we show that noxious or cooling agents inhibit the activity of GRPR neurons via GABAergic signaling. By contrast, capsaicin, which evokes a mix of itch and pain sensations, enhances both excitatory and inhibitory spontaneous synaptic transmission onto GRPR neurons. These data strengthen the role of GRPR neurons as a key circuit for itch transmission and illustrate a spinal mechanism whereby pain inhibits itch by suppressing the function of GRPR neurons.
1-nov-2019
9
1
15804
15804
Pain Inhibits GRPR Neurons via GABAergic Signaling in the Spinal Cord / Bardoni, Rita; Shen, Kai-Feng; Li, Hui; Jeffry, Joseph; Barry, Devin M.; Comitato, Antonella; Li, Yun-Qing; Chen, Zhou-Feng. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019), pp. 15804-15804. [10.1038/s41598-019-52316-0]
Bardoni, Rita; Shen, Kai-Feng; Li, Hui; Jeffry, Joseph; Barry, Devin M.; Comitato, Antonella; Li, Yun-Qing; Chen, Zhou-Feng
File in questo prodotto:
File Dimensione Formato  
Bardoni_2019.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 2.97 MB
Formato Adobe PDF
2.97 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1197273
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 17
social impact