The absence of detectable anti-HBc antibodies in some hepatitis B virus (HBV) infected patients may be due to altered core-protein (HBc) sequences. To investigate this possibility we sequenced the pre-C/C-region of HBV isolated from 12 juvenile cancer patients who incurred a nosocomial infection of HBV during chemotherapy but did not develop anti-HBc antibodies or acute cytolytic episodes. The sequences demonstrated the highest sequence homology to the pre-C/C region of a previously cloned HBV genome (subtype ayw) and no deletions or striking mutations were detected. Up to 7 years after infection almost all the survivors developed low titers of anti-HBc antibodies but no clinical signs of hepatic damage. These results suggest that chemotherapy may induce a tolerance status to HBcAg, the most immunogenic HBV protein.

CONSERVED CORE PROTEIN SEQUENCES IN HEPATITIS-B VIRUS-INFECTED PATIENTS WITHOUT ANTI-HBC / Melegari, M; Jung, Mc; Schneider, R; Santantonio, T; Bagnulo, S; Luchena, N; Pastore, G; Pape, G; Scaglioni, Pp; Villa, Erica; Will, H.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 13:(1991), pp. 187-191.

CONSERVED CORE PROTEIN SEQUENCES IN HEPATITIS-B VIRUS-INFECTED PATIENTS WITHOUT ANTI-HBC

VILLA, Erica;
1991

Abstract

The absence of detectable anti-HBc antibodies in some hepatitis B virus (HBV) infected patients may be due to altered core-protein (HBc) sequences. To investigate this possibility we sequenced the pre-C/C-region of HBV isolated from 12 juvenile cancer patients who incurred a nosocomial infection of HBV during chemotherapy but did not develop anti-HBc antibodies or acute cytolytic episodes. The sequences demonstrated the highest sequence homology to the pre-C/C region of a previously cloned HBV genome (subtype ayw) and no deletions or striking mutations were detected. Up to 7 years after infection almost all the survivors developed low titers of anti-HBc antibodies but no clinical signs of hepatic damage. These results suggest that chemotherapy may induce a tolerance status to HBcAg, the most immunogenic HBV protein.
13
187
191
CONSERVED CORE PROTEIN SEQUENCES IN HEPATITIS-B VIRUS-INFECTED PATIENTS WITHOUT ANTI-HBC / Melegari, M; Jung, Mc; Schneider, R; Santantonio, T; Bagnulo, S; Luchena, N; Pastore, G; Pape, G; Scaglioni, Pp; Villa, Erica; Will, H.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - STAMPA. - 13:(1991), pp. 187-191.
Melegari, M; Jung, Mc; Schneider, R; Santantonio, T; Bagnulo, S; Luchena, N; Pastore, G; Pape, G; Scaglioni, Pp; Villa, Erica; Will, H.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/11920
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