Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.
Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation / Monacelli, F.; Martella, L.; Parodi, M. N.; Odetti, P.; Fanelli, F.; Tabaton, M.. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 70:1(2019), pp. 11-15. [10.3233/JAD-190363]
Frontal Variant of Alzheimer's Disease: A Report of a Novel PSEN1 Mutation
Fanelli F.;
2019
Abstract
Alzheimer's disease may mimic frontotemporal dementia. We describe a case of presenile dementia who presented with peudo-psychotic symptoms carrying a PSEN1 mutation (P355S), which was not known to be pathogenic. PET-FDG showed bilateral frontotemporal hypometabolism, but at MRI, multiple microbleeds were detected, suggestive of amyloid angiopathy.
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