Introduction: This population-based study aims to evaluate the association between maternal pregestational diabetes and risk of acute lymphoblastic leukemia (ALL) in the offspring. Methods: All 241,958 children born in three Northern Italy provinces 1998–2010 were followed from birth until first cancer diagnosis (National Childhood Cancer Register), age 15 years, or 31 December 2017. We computed hazard ratio (HR) and 95% CI of ALL in relation to the presence of maternal diabetes through Cox proportional regression models. Results: We observed 145 cases of ALL, with a higher incidence in children born to women with pregestational diabetes compared to the others (12.4 vs 4.6). Adjusted hazard ratio of ALL was 2.6 (CI, 0.6–10.5) for maternal diabetes. Discussion: We estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Maternal pregestational diabetes and risk of acute lymphoblastic leukemia in the offspring: A population-based study in Northern Italy / Borsari, L.; Malagoli, C.; Della Torre, F.; Cellini, M.; Rodolfi, R.; Pession, A.; Vinceti, M.. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - 62(2019), pp. 101572--.
Data di pubblicazione: | 2019 |
Data di prima pubblicazione: | 20-lug-2019 |
Titolo: | Maternal pregestational diabetes and risk of acute lymphoblastic leukemia in the offspring: A population-based study in Northern Italy |
Autore/i: | Borsari, L.; Malagoli, C.; Della Torre, F.; Cellini, M.; Rodolfi, R.; Pession, A.; Vinceti, M. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.canep.2019.101572 |
Rivista: | |
Volume: | 62 |
Pagina iniziale: | 101572 |
Pagina finale: | - |
Codice identificativo ISI: | WOS:000492866900014 |
Codice identificativo Scopus: | 2-s2.0-85069571368 |
Codice identificativo Pubmed: | 31336345 |
Citazione: | Maternal pregestational diabetes and risk of acute lymphoblastic leukemia in the offspring: A population-based study in Northern Italy / Borsari, L.; Malagoli, C.; Della Torre, F.; Cellini, M.; Rodolfi, R.; Pession, A.; Vinceti, M.. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - 62(2019), pp. 101572--. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
1-s2.0-S1877782119300815-main.pdf | Versione dell'editore (versione pubblicata) | Administrator Richiedi una copia |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris