The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome this limitation, the use of nanocarriers for drug delivery across the BBB has recently been exploited. Nanocarriers can utilize different physiological mechanisms for drug delivery across the BBB and can be modified to achieve the desired kinetics and efficacy. Consequentially, several nanocarriers have been reported to act as functional nanomedicines in preclinical studies using animal models for human diseases. Given the rapid development of novel nanocarriers, this review provides a comprehensive insight into the most recent advancements made in nanocarrier-based drug delivery to the CNS, such as the development of multifunctional nanomedicines and theranostics.

Drug delivery across the blood–brain barrier: recent advances in the use of nanocarriers / Mulvihill, John JE; Cunnane, Eoghan M; Ross, Aisling M; Duskey, Jason T; Tosi, Giovanni; Grabrucker, Andreas M. - In: NANOMEDICINE. - ISSN 1743-5889. - 15:2(2020), pp. 205-214. [10.2217/nnm-2019-0367]

Drug delivery across the blood–brain barrier: recent advances in the use of nanocarriers

Duskey, Jason T;Tosi, Giovanni;
2020

Abstract

The blood-brain barrier (BBB) has a significant contribution to homeostasis and protection of the CNS. However, it also limits the crossing of therapeutics and thereby complicates the treatment of CNS disorders. To overcome this limitation, the use of nanocarriers for drug delivery across the BBB has recently been exploited. Nanocarriers can utilize different physiological mechanisms for drug delivery across the BBB and can be modified to achieve the desired kinetics and efficacy. Consequentially, several nanocarriers have been reported to act as functional nanomedicines in preclinical studies using animal models for human diseases. Given the rapid development of novel nanocarriers, this review provides a comprehensive insight into the most recent advancements made in nanocarrier-based drug delivery to the CNS, such as the development of multifunctional nanomedicines and theranostics.
15
2
205
214
Drug delivery across the blood–brain barrier: recent advances in the use of nanocarriers / Mulvihill, John JE; Cunnane, Eoghan M; Ross, Aisling M; Duskey, Jason T; Tosi, Giovanni; Grabrucker, Andreas M. - In: NANOMEDICINE. - ISSN 1743-5889. - 15:2(2020), pp. 205-214. [10.2217/nnm-2019-0367]
Mulvihill, John JE; Cunnane, Eoghan M; Ross, Aisling M; Duskey, Jason T; Tosi, Giovanni; Grabrucker, Andreas M
File in questo prodotto:
File Dimensione Formato  
Mulvhil et al, 2020, Nanomedicine nnm-2019-0367.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 4.26 MB
Formato Adobe PDF
4.26 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1188515
Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 67
  • ???jsp.display-item.citation.isi??? 64
social impact