(1) Background: valuation of the bioactivity and cytocompatibility of P2O5-free and CeO2 doped glasses. (2) Methods: all glasses are based on the Kokubo (K) composition and prepared by a melting method. Doped glassed, K1.2, K3.6 and K5.3 contain 1.2, 3.6, and 5.3 mol% of CeO2. Bioactivity and cytotoxicity tests were carried out in simulated body fluid (SBF) solution and murine osteocyte (MLO-Y4) cell lines, respectively. Leaching of ions concentration in SBF was determined by inductively coupled plasma mass spectrometry (ICP-MS) and optical emission spectrometry (ICP-OES). The surface of the glasses were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD) techniques. (3) Results: P2O5-free cerium doped glasses are proactive according to European directives. Cerium increases durability and retards, but does not inhibit, (Ca10(PO4)6(OH)2, HA) formation at higher cerium amounts (K3.6 and K5.3); however, cell proliferation increases with the amount of cerium especially evident for K5.3. (4) Conclusions: These results enforce the use of P2O5-free cerium doped bioactive glasses as a new class of biomaterials.
P2O5-free cerium containing glasses: Bioactivity and cytocompatibility evaluation / Lusvardi, G.; Stabellini, F. S.; Salvatori, R.. - In: MATERIALS. - ISSN 1996-1944. - 12:19(2019), pp. 1-13.
Data di pubblicazione: | 2019 |
Titolo: | P2O5-free cerium containing glasses: Bioactivity and cytocompatibility evaluation |
Autore/i: | Lusvardi, G.; Stabellini, F. S.; Salvatori, R. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/ma12193267 |
Rivista: | |
Volume: | 12 |
Fascicolo: | 19 |
Pagina iniziale: | 1 |
Pagina finale: | 13 |
Codice identificativo ISI: | WOS:000493308500216 |
Codice identificativo Scopus: | 2-s2.0-85073713153 |
Codice identificativo Pubmed: | 31597232 |
Citazione: | P2O5-free cerium containing glasses: Bioactivity and cytocompatibility evaluation / Lusvardi, G.; Stabellini, F. S.; Salvatori, R.. - In: MATERIALS. - ISSN 1996-1944. - 12:19(2019), pp. 1-13. |
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