Motorized traffic exposure and particularly benzene have been associated to childhood leukemia. In particular, living next to a petrol station or repair garage may increase the opportunity for benzene exposure. In this review, we investigated the extent to which living in proximity to petrol stations is associated with risk of childhood leukemia. We searched all observational studies that have investigated the risk of childhood leukemia in relation to exposure to petrol station using either proximity of children residence or modelled exposure. We performed online database search up to October 10, 2019, including also snowballing methods to retrieve all possible eligible studies. We carried out a meta-analysis of all eligible studies using a random effect model. We found six studies eligible to be included in our review published from 1999 to 2019 and all with all with a case-control design. We identified two additional studies compared to the last published systematic review, including one conference abstract. Exposure assessment was performed using questionnaire or face-to-face interview asking for distance of residence to petrol station in three studies (in one case with external validation), while georeferencing method was used using either distance (two studies) or petrol station density (one study). We eventually included 3632 cases and 21874 controls in the analysis. Summary relative risk (sRR) was 1.63 (95% CI 1.11 to 2.50). After exclusion of one study in which exposure to either petrol station and automotive repair was considered, we still found an increased sRR of 1.48 (95% CI 1.03 to 2.12). Comparable risk was reported after stratification of exposure assessment method. Estimates were slightly higher for ALL (sRR=3.31, 95% CI 0.92 to 11.86) compared with AML (sRR=2.06, 95% CI 0.90 to 4.70), although based on only two studies. Overall, the epidemiologic literature appears to support an association between living in proximity to petrol station and childhood leukemia risk, particularly ALL, supporting previous findings regarding motorized traffic and particularly benzene.
Proximity to petrol station and risk of childhood leukemia: systematic review and meta-analysis / Filippini, Tommaso; Malagoli, Carlotta; Vinceti, Marco. - (2019). ((Intervento presentato al convegno 2019 Childhood Leukemia International Consortium Meeting tenutosi a Lyon, France nel 18-20 November 2019.
|Data di pubblicazione:||2019|
|Titolo:||Proximity to petrol station and risk of childhood leukemia: systematic review and meta-analysis|
|Autore/i:||Filippini, Tommaso; Malagoli, Carlotta; Vinceti, Marco|
|Nome del convegno:||2019 Childhood Leukemia International Consortium Meeting|
|Data del convegno:||18-20 November 2019|
|Luogo del convegno:||Lyon, France|
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