the catalytic p110gamma of PI3K is implicated in the survival and proliferation of CLL cells. Our findings support the idea that CLL cells are peculiar in the attitude to sense microenvironmental signals throughout the engagement of multiple PI3Ks. PI3Kgamma inhibition by IPI-549 may directly promote CLL apoptosis, but may also interfere with signals derived from several accessory cells of stromal and immune system. Together with the reported ability of PI3Kgamma inhibition in prevention of CLL migration and adhesion, our data provide knowledge to justify further clinical development of PI3Kc inhibition in CLL cells.
Selective inhibition of PI3Kγ affects survival and proliferation of chronic lymphocytic leukemia B cells / Maffei, R.; Benatti, S.; Atene, C. G.; Debbia, G.; Zucchini, P.; Potenza, L.; Luppi, M.; Fiorcari, S.; Marasca, R.. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - 61:2(2020), pp. 455-459. [10.1080/10428194.2019.1666376]
Selective inhibition of PI3Kγ affects survival and proliferation of chronic lymphocytic leukemia B cells
Maffei R.
Writing – Original Draft Preparation
;Benatti S.Formal Analysis
;Atene C. G.Formal Analysis
;Debbia G.Data Curation
;Zucchini P.;Potenza L.Membro del Collaboration Group
;Luppi M.Supervision
;Fiorcari S.Writing – Review & Editing
;Marasca R.Writing – Review & Editing
2020
Abstract
the catalytic p110gamma of PI3K is implicated in the survival and proliferation of CLL cells. Our findings support the idea that CLL cells are peculiar in the attitude to sense microenvironmental signals throughout the engagement of multiple PI3Ks. PI3Kgamma inhibition by IPI-549 may directly promote CLL apoptosis, but may also interfere with signals derived from several accessory cells of stromal and immune system. Together with the reported ability of PI3Kgamma inhibition in prevention of CLL migration and adhesion, our data provide knowledge to justify further clinical development of PI3Kc inhibition in CLL cells.
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