The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learning. More importantly, the "molecular actors" of the memory dialogue are well-conserved both across phylogenetic groups and learning paradigms, involving single- or multi-trials, aversion or reward, operant or classical conditioning. At the same time, this model could help to study how, where and when the memory dialog is impaired in stressful conditions and during aging and neurodegeneration in humans and thus offers new insights and targets in order to develop innovative therapies and technology for the treatment of a range of neurological and neurodegenerative disorders.

Lymnaea stagnalis as model for translational neuroscience research: from pond to bench / Rivi, Veronica; Benatti, C; Colliva, C; Radighieri, G; Brunello, N; Tascedda, F; Blom, Johanna. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - 108:(2020), pp. 602-616. [10.1016/j.neubiorev.2019.11.020]

Lymnaea stagnalis as model for translational neuroscience research: from pond to bench

RIVI, VERONICA;Benatti, C;Colliva, C;Radighieri, G;Brunello, N;Tascedda, F;Blom, Johanna
2020

Abstract

The purpose of this review is to illustrate how a reductionistic, but sophisticated, approach based on the use of a simple model system such as the pond snail Lymnaea stagnalis (L. stagnalis), might be useful to address fundamental questions in learning and memory. L. stagnalis, as a model, provides an interesting platform to investigate the dialog between the synapse and the nucleus and vice versa during memory and learning. More importantly, the "molecular actors" of the memory dialogue are well-conserved both across phylogenetic groups and learning paradigms, involving single- or multi-trials, aversion or reward, operant or classical conditioning. At the same time, this model could help to study how, where and when the memory dialog is impaired in stressful conditions and during aging and neurodegeneration in humans and thus offers new insights and targets in order to develop innovative therapies and technology for the treatment of a range of neurological and neurodegenerative disorders.
2020
28-nov-2019
108
602
616
Lymnaea stagnalis as model for translational neuroscience research: from pond to bench / Rivi, Veronica; Benatti, C; Colliva, C; Radighieri, G; Brunello, N; Tascedda, F; Blom, Johanna. - In: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. - ISSN 0149-7634. - 108:(2020), pp. 602-616. [10.1016/j.neubiorev.2019.11.020]
Rivi, Veronica; Benatti, C; Colliva, C; Radighieri, G; Brunello, N; Tascedda, F; Blom, Johanna
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0149763419306542-main.pdf

Open access

Tipologia: Versione dell'autore revisionata e accettata per la pubblicazione
Dimensione 3.48 MB
Formato Adobe PDF
3.48 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1185834
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 45
  • ???jsp.display-item.citation.isi??? 44
social impact