The role of damage-associated molecular patterns in multiple sclerosis (MS) is under investigation. Here, we studied the contribution of circulating high mobility group box protein 1 (HMGB1) and mitochondrial DNA (mtDNA) to neuroinflammation in progressive MS. We measured plasmatic mtDNA, HMGB1 and pro-inflammatory cytokines in 38 secondary progressive (SP) patients, 35 primary progressive (PP) patients and 42 controls. Free mtDNA was higher in SP than PP. Pro-inflammatory cytokines were increased in progressive patients. In PP, tumor necrosis factor-α correlated with MS Severity Score. Thus, in progressive patients, plasmatic mtDNA and pro-inflammatory cytokines likely contribute to the systemic inflammatory status.
Increased plasma levels of mitochondrial DNA and pro-inflammatory cytokines in patients with progressive multiple sclerosis / Nasi, M., Bianchini, E., De Biasi, S., Gibellini, L., Neroni, A., Mattioli, M., Pinti, M., Iannone, A., Mattioli, A.V., Simone, A.M., Ferraro, D., Vitetta, F., Sola, P., Cossarizza, A.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 338:(2020), pp. 577107-577111. [10.1016/j.jneuroim.2019.577107]
Increased plasma levels of mitochondrial DNA and pro-inflammatory cytokines in patients with progressive multiple sclerosis
Nasi M.
;Bianchini E.;De Biasi S.;Gibellini L.;Neroni A.;Mattioli, Marco;Pinti M.;Iannone A.;Mattioli A. V.;Simone A. M.;Ferraro D.;Sola P.;Cossarizza A.
2020
Abstract
The role of damage-associated molecular patterns in multiple sclerosis (MS) is under investigation. Here, we studied the contribution of circulating high mobility group box protein 1 (HMGB1) and mitochondrial DNA (mtDNA) to neuroinflammation in progressive MS. We measured plasmatic mtDNA, HMGB1 and pro-inflammatory cytokines in 38 secondary progressive (SP) patients, 35 primary progressive (PP) patients and 42 controls. Free mtDNA was higher in SP than PP. Pro-inflammatory cytokines were increased in progressive patients. In PP, tumor necrosis factor-α correlated with MS Severity Score. Thus, in progressive patients, plasmatic mtDNA and pro-inflammatory cytokines likely contribute to the systemic inflammatory status.
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