Sperm chromatin integrity is essential for normal embryo development and pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to measure the proportion of sperm with damaged chromatin in the ejaculate. SDF is associated with potentially treatable conditions, including varicocele, male accessory gland infections, inadequate lifestyle, and gonadotoxin exposure, thus prompting their treatment as a means of improving sperm DNA quality and the reproductive outcomes.
An Update on Clinical and Surgical Interventions to Reduce Sperm DNA Fragmentation in Infertile Men / Esteves, Sandro C; Santi, Daniele; Simoni, Manuela. - In: ANDROLOGY. - ISSN 2047-2919. - 8:1(2020), pp. 53-81. [10.1111/andr.12724]
An Update on Clinical and Surgical Interventions to Reduce Sperm DNA Fragmentation in Infertile Men
Santi, Daniele;Simoni, Manuela
2020
Abstract
Sperm chromatin integrity is essential for normal embryo development and pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to measure the proportion of sperm with damaged chromatin in the ejaculate. SDF is associated with potentially treatable conditions, including varicocele, male accessory gland infections, inadequate lifestyle, and gonadotoxin exposure, thus prompting their treatment as a means of improving sperm DNA quality and the reproductive outcomes.
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Andrology - 2019 - Esteves - An update on clinical and surgical interventions to reduce sperm DNA fragmentation in.pdf
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