Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. (C) 2013 AACR.
P63, Sharp1, and HIFs: Master regulators of metastasis in triple-negative breast cance / Piccolo, S.; Enzo, E.; Montagner, M.. - In: CANCER RESEARCH. - ISSN 0008-5472. - 73:16(2013), pp. 4978-4981. [10.1158/0008-5472.CAN-13-0962]