Solar lentigo, benign lesions which mostly appear on chronically, sun-exposed surfaces, are associated with ageing. Patients are increasingly requesting a more uniform skin texture, especially for hands. Treatment options include dermoabrasion, intense pulsed light, cryotherapy, peelings, and laser therapy. Topical compounds can be employed, in alternative or associated with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p = 0.03) and contrast (p = 0.03), and in the limitation of dermal-epidermal junction destructuring (p = 0.03) according to dermal-epidermal junction destructuring score at Reflectance Confocal Microscopy. Luminance (p = 0.04) and redness (p = 0.03) were improved at color analysis, and physician and patient evaluations favored the active in efficacy and patient satisfaction investigations. The dermocosmetic lightening product utilized in the current study proved to be more effective, according to clinical, digital and subjective analyses in reducing lesion hyperpigmentation, stabilizing the lesion skin architecture and increasing patient satisfaction compared to the control in a cohort of 36 subjects, over a 12-month period. Beside demonstrating the efficacy of this topical lightening product, we propose a "destructuring score", which improves the robustness of solar lentigo's evaluation, and can be used in future studies to standardize the quantitative comparisons of different treatment options.
|Data di pubblicazione:||2019|
|Titolo:||Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial|
|Autore/i:||Arginelli, F.; Greco, M.; Ciardo, S.; Josse, G.; Rossi, A. B.; Le Digabel, J.; Questel, E.; Chester, J.; Pellacani, G.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1371/journal.pone.0214714|
|Codice identificativo ISI:||WOS:000466370200015|
|Codice identificativo Scopus:||2-s2.0-85065482971|
|Codice identificativo Pubmed:||31042723|
|Citazione:||Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial / Arginelli, F.; Greco, M.; Ciardo, S.; Josse, G.; Rossi, A. B.; Le Digabel, J.; Questel, E.; Chester, J.; Pellacani, G.. - In: PLOS ONE. - ISSN 1932-6203. - 14:5(2019), pp. e0214714-e0214714.|
|Tipologia||Articolo su rivista|
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris