Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice / Schafer, Peter H; Adams, Mary; Horan, Gerald; Truzzi, Francesca; Marconi, Alessandra; Pincelli, Carlo. - In: DRUGS IN R&D. - ISSN 1174-5886. - 19:(2019), pp. 329-338. [10.1007/s40268-019-00284-1]
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice
Truzzi, Francesca;Marconi, Alessandra;Pincelli, Carlo
2019-01-01
Abstract
Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.
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