Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice / Schafer, Peter H; Adams, Mary; Horan, Gerald; Truzzi, Francesca; Marconi, Alessandra; Pincelli, Carlo. - In: DRUGS IN R&D. - ISSN 1174-5886. - 19:4(2019), pp. 329-338. [10.1007/s40268-019-00284-1]
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice
Truzzi, Francesca;Marconi, Alessandra;Pincelli, Carlo
2019
Abstract
Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Schafer2019_Article_ApremilastNormalizesGeneExpres.pdf
Open access
Tipologia:
Versione pubblicata dall'editore
Dimensione
2.86 MB
Formato
Adobe PDF
|
2.86 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
