Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice / Schafer, Peter H; Adams, Mary; Horan, Gerald; Truzzi, Francesca; Marconi, Alessandra; Pincelli, Carlo. - In: DRUGS IN R&D. - ISSN 1174-5886. - 19:4(2019), pp. 329-338. [10.1007/s40268-019-00284-1]

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice

Truzzi, Francesca;Marconi, Alessandra;Pincelli, Carlo
2019

Abstract

Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromised epidermal barrier.
2019
19
4
329
338
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice / Schafer, Peter H; Adams, Mary; Horan, Gerald; Truzzi, Francesca; Marconi, Alessandra; Pincelli, Carlo. - In: DRUGS IN R&D. - ISSN 1174-5886. - 19:4(2019), pp. 329-338. [10.1007/s40268-019-00284-1]
Schafer, Peter H; Adams, Mary; Horan, Gerald; Truzzi, Francesca; Marconi, Alessandra; Pincelli, Carlo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1182980
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