ObjectiveTo investigate if the association between MRI-detectable white matter hyperintensity (WMH) and cognitive status reported in previous studies persists at older ages (>80 years), when some white matter abnormality is almost universally reported in clinical practice.MethodsConsecutive eligible patients from a population-based cohort of all TIA/nondisabling stroke (Oxford Vascular Study) underwent multimodal MRI, including fluid-Attenuated inversion recovery and diffusion-weighted imaging, allowing automated measurement of WMH volume, mean diffusivity (MD), and fractional anisotropy (FA) in normal-Appearing white matter using FSL tools. These measures were related to cognitive status (Montreal Cognitive Assessment) at age ≤80 vs >80 years.ResultsOf 566 patients (mean [range] age 66.7 [20-102] years), 107 were aged >80 years. WMH volumes and MD/FA were strongly associated with cognitive status in patients aged ≤80 years (all p < 0.001 for WMH, MD, and FA) but not in patients aged >80 years (not significant for WMH, MD, and FA), with age interactions for WMH volume (pinteraction = 0.016) and MD (pinteraction = 0.037). Voxel-wise analyses also showed that lower Montreal Cognitive Assessment scores were associated with frontal WMH in patients ≤80 years, but not >80 years.ConclusionMRI markers of white matter damage are strongly related to cognition in patients with TIA/minor stroke at younger ages, but not at age >80 years. Clinicians and patients should not overinterpret the significance of these abnormalities at older ages.
Age-dependent association of white matter abnormality with cognition after TIA or minor stroke / Zamboni, G.; Griffanti, L.; Mazzucco, S.; Pendlebury, S. T.; Rothwell, P. M.. - In: NEUROLOGY. - ISSN 0028-3878. - 93:3(2019), pp. E272-E282.
|Data di pubblicazione:||2019|
|Data di prima pubblicazione:||14-giu-2019|
|Titolo:||Age-dependent association of white matter abnormality with cognition after TIA or minor stroke|
|Autore/i:||Zamboni, G.; Griffanti, L.; Mazzucco, S.; Pendlebury, S. T.; Rothwell, P. M.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1212/WNL.0000000000007772|
|Codice identificativo ISI:||WOS:000480787500006|
|Codice identificativo Scopus:||2-s2.0-85069948084|
|Codice identificativo Pubmed:||31201296|
|Citazione:||Age-dependent association of white matter abnormality with cognition after TIA or minor stroke / Zamboni, G.; Griffanti, L.; Mazzucco, S.; Pendlebury, S. T.; Rothwell, P. M.. - In: NEUROLOGY. - ISSN 0028-3878. - 93:3(2019), pp. E272-E282.|
|Tipologia||Articolo su rivista|
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