Cerebrospinal fluid (CSF) and blood neurofilaments (NFLs) are markers of axonal damage and are being investigated, mostly in relapsing-remitting (RR) MS, as a marker of disease activity and of response to treatment, while there are less data in progressive MS patients. Primary aim was to measure NFL in plasma samples of untreated patients with primary (PP) and secondary (SP) progressive MS and to correlate them with disability, disease severity, and prior/subsequent disability progression.
Plasma neurofilaments correlate with disability in progressive multiple sclerosis patients / Ferraro, Diana; Guicciardi, Claudio; De Biasi, Sara; Pinti, Marcello; Bedin, Roberta; Camera, Valentina; Vitetta, Francesca; Nasi, Milena; Meletti, Stefano; Sola, Patrizia. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - 141:1(2020), pp. 16-21. [10.1111/ane.13152]
Plasma neurofilaments correlate with disability in progressive multiple sclerosis patients
Ferraro, Diana;De Biasi, Sara;Pinti, Marcello;Bedin, Roberta;Camera, Valentina;Nasi, Milena;Meletti, Stefano;
2020
Abstract
Cerebrospinal fluid (CSF) and blood neurofilaments (NFLs) are markers of axonal damage and are being investigated, mostly in relapsing-remitting (RR) MS, as a marker of disease activity and of response to treatment, while there are less data in progressive MS patients. Primary aim was to measure NFL in plasma samples of untreated patients with primary (PP) and secondary (SP) progressive MS and to correlate them with disability, disease severity, and prior/subsequent disability progression.
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