Enteroviruses (EVs) are an important cause of illness, especially in neonates and young infants. Clinical and laboratory findings at different ages, brain imaging, and outcomes have been inadequately investigated.

Background Enteroviruses (EVs) are an important cause of illness, especially in neonates and young infants. Clinical and laboratory findings at different ages, brain imaging, and outcomes have been inadequately investigated. Methods We retrospectively investigated EV infections occurring at an Italian tertiary care center during 2006-2017. Cases were confirmed with a positive polymerase chain reaction on blood or cerebrospinal fluid. Clinical and laboratory findings according to age at presentation were analyzed. Results Among 61 cases of EV infection, 56 had meningitis, 4 had encephalitis, and 1 had unspecific febrile illness. Forty-seven cases (77.0%) presented at less than 1 year of age, and most were less than 90 days of age (n = 44). Presentation with fever (p < 0.01), higher median temperature (p < 0.01), and irritability (p < 0.01) were significantly more common among infants aged less than 90 days, who also had significantly higher peak temperatures during the course of the disease (p < 0.01). In contrast, gastrointestinal symptoms were more common in infants and children aged over 90 days (p = 0.02). Only 4 of 61 infections (6.5%) were severe and all affected younger infants (p < 0.01). Conclusions We detail epidemiological, clinical, and laboratory findings in a cohort of 61 children. Infants aged less than 90 days have more severe disease; they are more likely to present with fever, higher median temperature, and irritability and less likely to develop gastrointestinal symptoms.

Clinical characterization of neonatal and pediatric enteroviral infections: an Italian single center study / Berardi, Alberto; Sandoni, Marcello; Toffoli, Carlotta; Boncompagni, Alessandra; Gennari, William; Bergamini, Maria Barbara; Lucaccioni, Laura; Iughetti, Lorenzo. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 45:1(2019), pp. 1-8. [10.1186/s13052-019-0689-8]

Clinical characterization of neonatal and pediatric enteroviral infections: an Italian single center study

Berardi, Alberto;Toffoli, Carlotta;Boncompagni, Alessandra;Bergamini, Maria Barbara;Lucaccioni, Laura;Iughetti, Lorenzo
2019

Abstract

Background Enteroviruses (EVs) are an important cause of illness, especially in neonates and young infants. Clinical and laboratory findings at different ages, brain imaging, and outcomes have been inadequately investigated. Methods We retrospectively investigated EV infections occurring at an Italian tertiary care center during 2006-2017. Cases were confirmed with a positive polymerase chain reaction on blood or cerebrospinal fluid. Clinical and laboratory findings according to age at presentation were analyzed. Results Among 61 cases of EV infection, 56 had meningitis, 4 had encephalitis, and 1 had unspecific febrile illness. Forty-seven cases (77.0%) presented at less than 1 year of age, and most were less than 90 days of age (n = 44). Presentation with fever (p < 0.01), higher median temperature (p < 0.01), and irritability (p < 0.01) were significantly more common among infants aged less than 90 days, who also had significantly higher peak temperatures during the course of the disease (p < 0.01). In contrast, gastrointestinal symptoms were more common in infants and children aged over 90 days (p = 0.02). Only 4 of 61 infections (6.5%) were severe and all affected younger infants (p < 0.01). Conclusions We detail epidemiological, clinical, and laboratory findings in a cohort of 61 children. Infants aged less than 90 days have more severe disease; they are more likely to present with fever, higher median temperature, and irritability and less likely to develop gastrointestinal symptoms.
2019
45
1
1
8
Clinical characterization of neonatal and pediatric enteroviral infections: an Italian single center study / Berardi, Alberto; Sandoni, Marcello; Toffoli, Carlotta; Boncompagni, Alessandra; Gennari, William; Bergamini, Maria Barbara; Lucaccioni, Laura; Iughetti, Lorenzo. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 45:1(2019), pp. 1-8. [10.1186/s13052-019-0689-8]
Berardi, Alberto; Sandoni, Marcello; Toffoli, Carlotta; Boncompagni, Alessandra; Gennari, William; Bergamini, Maria Barbara; Lucaccioni, Laura; Iughet...espandi
File in questo prodotto:
File Dimensione Formato  
Enterovirus, caratterizzazione clinica (Berardi_Ital J ed 2019).pdf

Open access

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 802.96 kB
Formato Adobe PDF
802.96 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1179759
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact