Sirolimus (SIR) is a potent immunosuppressive agent with multiple proprieties. We report beneficial antiviral effects of SIR in an HIV-positive kidney transplant recipient who experienced low-level HIV-1 replication. The immunosuppressive agent was well tolerated by the patient, and no side effects were reported during follow-up. Despite immunosuppressive monotherapy, SIR ensured stable graft function.
Antiviral activity of sirolimus in an HIV-positive kidney transplant recipient / Alfano, G.; Fontana, F.; Mori, G.; Vicari, Emanuela; Dolci, G.; Franceschini, E.; Guaraldi, G.; Mussini, C.; Cappelli, G.. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - 30:9(2019), pp. 919-922. [10.1177/0956462419839520]
Antiviral activity of sirolimus in an HIV-positive kidney transplant recipient
Alfano G.;Fontana F.;Mori G.;VICARI, EMANUELA;Dolci G.;Franceschini E.;Guaraldi G.;Mussini C.;Cappelli G.
2019
Abstract
Sirolimus (SIR) is a potent immunosuppressive agent with multiple proprieties. We report beneficial antiviral effects of SIR in an HIV-positive kidney transplant recipient who experienced low-level HIV-1 replication. The immunosuppressive agent was well tolerated by the patient, and no side effects were reported during follow-up. Despite immunosuppressive monotherapy, SIR ensured stable graft function.
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