Monitoring of prescription pain medications is strongly recommended, considering their abuse liability. We used hair analysis for monitoring pain medications in 12 women with chronic migraine and drug overuse. Hair samples were collected at baseline and after 4 and 8 months and analyzed by liquid chromatography‐electrospray tandem mass spectrometry (LC‐MS/MS). Intrapatient variability of the hair level‐to‐dose ratio was < 20% in most cases. The hair analysis detected changes in the dose taken by the same patient over time, both occasionally and chronically. The agreement between the changes in hair drug levels and those of taken doses was excellent. Therefore, hair analysis appeared advantageous for long‐term monitoring of pain medications, which is otherwise difficult to determine in conventional matrices. In the same sample, multiple medications could be simultaneously determined, and with three samples, nine months of therapy were objectively documented.

Intrapatient variability of the hair levels of pain medications in chronic migraine patients - a pilot study / Ferrari, Anna; Rustichelli, Cecilia; Baraldi, Carlo; Vandelli, Daniele; Verri, Patrizia; Marchesi, Filippo; Licata, Manuela. - In: DRUG TESTING AND ANALYSIS. - ISSN 1942-7603. - 11:(2019), pp. 878-885. [10.1002/dta.2560]

Intrapatient variability of the hair levels of pain medications in chronic migraine patients - a pilot study

Ferrari, Anna;Rustichelli, Cecilia
;
Baraldi, Carlo;Vandelli, Daniele;Verri, Patrizia;Marchesi, Filippo;Licata, Manuela
2019

Abstract

Monitoring of prescription pain medications is strongly recommended, considering their abuse liability. We used hair analysis for monitoring pain medications in 12 women with chronic migraine and drug overuse. Hair samples were collected at baseline and after 4 and 8 months and analyzed by liquid chromatography‐electrospray tandem mass spectrometry (LC‐MS/MS). Intrapatient variability of the hair level‐to‐dose ratio was < 20% in most cases. The hair analysis detected changes in the dose taken by the same patient over time, both occasionally and chronically. The agreement between the changes in hair drug levels and those of taken doses was excellent. Therefore, hair analysis appeared advantageous for long‐term monitoring of pain medications, which is otherwise difficult to determine in conventional matrices. In the same sample, multiple medications could be simultaneously determined, and with three samples, nine months of therapy were objectively documented.
21-dic-2018
11
878
885
Intrapatient variability of the hair levels of pain medications in chronic migraine patients - a pilot study / Ferrari, Anna; Rustichelli, Cecilia; Baraldi, Carlo; Vandelli, Daniele; Verri, Patrizia; Marchesi, Filippo; Licata, Manuela. - In: DRUG TESTING AND ANALYSIS. - ISSN 1942-7603. - 11:(2019), pp. 878-885. [10.1002/dta.2560]
Ferrari, Anna; Rustichelli, Cecilia; Baraldi, Carlo; Vandelli, Daniele; Verri, Patrizia; Marchesi, Filippo; Licata, Manuela
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1178941
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