Epidermal growth factor receptor (EGFR) is usually expressed in squamous cell anal carcinoma (SCAC) and anti-EGFR agents could represent a valid treatment strategy, also considering that KRAS and BRAF mutations are rare events in this type of cancer. However, no data are available on NRAS status in SCAC. In this study we analyzed NRAS status (exons 2-4) by Pyrosequencing in a case series of 50 SCAC patients previously characterized in our laboratory for KRAS, BRAF, PIK3CA mutations and HPV and HIV infections. We found no mutation in NRAS gene. These results confirm that since the principal anti-EGFR resistance mechanisms are almost absent in SCAC, anti-EGFR agents should be considered for the treatment of this type of cancer.
No evidence of NRAS mutation in squamous cell anal carcinoma (SCAC) / Capelli, Laura; Casadei Gardini, Andrea; Scarpi, Emanuela; Frassineti, Giovanni Luca; Saragoni, Luca; Puccetti, Maurizio; Scartozzi, Mario; Giannini, MASSIMO CARLO; Tamberi, Stefano; Corbelli, Jody; Ulivi, Paola. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:(2016), pp. 1-5. [10.1038/srep37621]
No evidence of NRAS mutation in squamous cell anal carcinoma (SCAC)
Casadei Gardini, Andrea;Scartozzi, Mario;GIANNINI, MASSIMO CARLO;Tamberi, Stefano;
2016
Abstract
Epidermal growth factor receptor (EGFR) is usually expressed in squamous cell anal carcinoma (SCAC) and anti-EGFR agents could represent a valid treatment strategy, also considering that KRAS and BRAF mutations are rare events in this type of cancer. However, no data are available on NRAS status in SCAC. In this study we analyzed NRAS status (exons 2-4) by Pyrosequencing in a case series of 50 SCAC patients previously characterized in our laboratory for KRAS, BRAF, PIK3CA mutations and HPV and HIV infections. We found no mutation in NRAS gene. These results confirm that since the principal anti-EGFR resistance mechanisms are almost absent in SCAC, anti-EGFR agents should be considered for the treatment of this type of cancer.
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