EnglishFluxes of calcium ions (Ca2+) in rod photoreceptors are major regulators of steady-state and light-evoked intracellular reactions to stimuli. The homeostasis of Ca2+ is regulated by channels and pumps localized at the plasma membrane and in intracellular organelles. Photoreceptor degeneration is frequently associated with Ca2+ homeostasis disruption and stimulation of Ca2+ activated proteases, such as calpains. These events trigger molecular pathways leading to cell death. In this chapter we discuss Ca2+ channels and pumps as well as calpains as potential targets of new therapies for retinal degeneration.
CHAPTER 3. Modulation of Calcium Overload and Calpain Activity / Paquet-Durand, François; Ekström, Per; Marigo, Valeria. - 2019:66(2019), pp. 48-60.
| Data di pubblicazione: | 2019 |
| Titolo: | CHAPTER 3. Modulation of Calcium Overload and Calpain Activity |
| Autore/i: | Paquet-Durand, François; Ekström, Per; Marigo, Valeria |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/9781788013666-00048 |
| Codice identificativo Scopus: | 2-s2.0-85056592063 |
| Serie: | RSC DRUG DISCOVERY SERIES |
| Titolo del libro: | RSC Drug Discovery Series |
| Citazione: | CHAPTER 3. Modulation of Calcium Overload and Calpain Activity / Paquet-Durand, François; Ekström, Per; Marigo, Valeria. - 2019:66(2019), pp. 48-60. |
| Tipologia | Capitolo/Saggio |
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