The industrial production of chondroitin sulfate (CS) uses animal tissue sources as raw material derived from dierent terrestrial or marine species of animals. CS possesses a heterogeneous structure and physical-chemical profile in dierent species and tissues, responsible for the various and more specialized functions of these macromolecules. Moreover, mixes of dierent animal tissues and sources are possible, producing a CS final product having varied characteristics and not well identified profile, influencing oral absorption and activity. Finally, dierent extraction and purification processes may introduce further modifications of the CS structural characteristics and properties and may lead to extracts having a variable grade of purity, limited biological eects, presence of contaminants causing problems of safety and reproducibility along with not surely identified origin. These aspects pose a serious problem for the final consumers of the pharmaceutical or nutraceutical products mainly related to the traceability of CS and to the declaration of the real origin of the active ingredient and its content. In this review, specific, sensitive and validated analytical quality controls such as electrophoresis, eHPLC (enzymatic HPLC) and HPSEC (high-performance size-exclusion chromatography) able to assure CS quality and origin are illustrated and discussed.

Chondroitin Sulfate Safety and Quality / Volpi, N.. - In: MOLECULES. - ISSN 1420-3049. - 24:8(2019), pp. 1447-1460. [10.3390/molecules24081447]

Chondroitin Sulfate Safety and Quality.

Volpi N.
2019

Abstract

The industrial production of chondroitin sulfate (CS) uses animal tissue sources as raw material derived from dierent terrestrial or marine species of animals. CS possesses a heterogeneous structure and physical-chemical profile in dierent species and tissues, responsible for the various and more specialized functions of these macromolecules. Moreover, mixes of dierent animal tissues and sources are possible, producing a CS final product having varied characteristics and not well identified profile, influencing oral absorption and activity. Finally, dierent extraction and purification processes may introduce further modifications of the CS structural characteristics and properties and may lead to extracts having a variable grade of purity, limited biological eects, presence of contaminants causing problems of safety and reproducibility along with not surely identified origin. These aspects pose a serious problem for the final consumers of the pharmaceutical or nutraceutical products mainly related to the traceability of CS and to the declaration of the real origin of the active ingredient and its content. In this review, specific, sensitive and validated analytical quality controls such as electrophoresis, eHPLC (enzymatic HPLC) and HPSEC (high-performance size-exclusion chromatography) able to assure CS quality and origin are illustrated and discussed.
2019
24
8
1447
1460
Chondroitin Sulfate Safety and Quality / Volpi, N.. - In: MOLECULES. - ISSN 1420-3049. - 24:8(2019), pp. 1447-1460. [10.3390/molecules24081447]
Volpi, N.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1175857
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