The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.

A "systems medicine" approach to the study of non-alcoholic fatty liver disease / Petta, Salvatore; Valenti, Luca; Bugianesi, Elisabetta; Targher, Giovanni; Bellentani, Stefano; Bonino, Ferruccio; Fargion, Silvia; Vanni, Ester; Ferrannini, Ele; Loguercio, Carmela; Lonardo, Amedeo; Marra, Fabio; Mancini, Marcello; Miele, Luca; Nobili, Valerio; Baroni, Gianluca Svegliati; Alessandro, Federico; Ballestri, Stefano; Brunetto, Maurizia Rossana; Coco, Barbara; Grieco, Antonio; Kondili, Loreta; Nascimbeni, Fabio; Prinster, Anna; Romagnoli, Dante; Taddei, Stefano; Vella, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 48:3(2016), pp. 333-342. [10.1016/j.dld.2015.10.027]

A "systems medicine" approach to the study of non-alcoholic fatty liver disease

Fargion, Silvia;Alessandro, Federico;Ballestri, Stefano;Nascimbeni, Fabio;Romagnoli, Dante;
2016

Abstract

The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g. the definition of risk, prognosis, diagnosis criteria, and new endpoints of clinical trials). Based on this premise and in light of recent findings, the complex mechanisms involved in the pathology of fatty liver and their impact on the short- and long-term clinical outcomes of cardiovascular, metabolic liver diseases associated with steatosis are presented in this review using a new "systems medicine" approach. A new data set is proposed for studying the impairments of different physiological systems that have an impact on fatty liver in different subsets of subjects and patients.
48
3
333
342
A "systems medicine" approach to the study of non-alcoholic fatty liver disease / Petta, Salvatore; Valenti, Luca; Bugianesi, Elisabetta; Targher, Giovanni; Bellentani, Stefano; Bonino, Ferruccio; Fargion, Silvia; Vanni, Ester; Ferrannini, Ele; Loguercio, Carmela; Lonardo, Amedeo; Marra, Fabio; Mancini, Marcello; Miele, Luca; Nobili, Valerio; Baroni, Gianluca Svegliati; Alessandro, Federico; Ballestri, Stefano; Brunetto, Maurizia Rossana; Coco, Barbara; Grieco, Antonio; Kondili, Loreta; Nascimbeni, Fabio; Prinster, Anna; Romagnoli, Dante; Taddei, Stefano; Vella, Stefano. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 48:3(2016), pp. 333-342. [10.1016/j.dld.2015.10.027]
Petta, Salvatore; Valenti, Luca; Bugianesi, Elisabetta; Targher, Giovanni; Bellentani, Stefano; Bonino, Ferruccio; Fargion, Silvia; Vanni, Ester; Ferrannini, Ele; Loguercio, Carmela; Lonardo, Amedeo; Marra, Fabio; Mancini, Marcello; Miele, Luca; Nobili, Valerio; Baroni, Gianluca Svegliati; Alessandro, Federico; Ballestri, Stefano; Brunetto, Maurizia Rossana; Coco, Barbara; Grieco, Antonio; Kondili, Loreta; Nascimbeni, Fabio; Prinster, Anna; Romagnoli, Dante; Taddei, Stefano; Vella, Stefano
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S159086581500691X-main.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 1.52 MB
Formato Adobe PDF
1.52 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1175090
Citazioni
  • ???jsp.display-item.citation.pmc??? 25
  • Scopus 58
  • ???jsp.display-item.citation.isi??? 48
social impact