Pistacia lentiscus L. (PL) is an evergreen shrub from which it is derived a precious aromatic resin called mastic gum or mastic. This extract possesses numerous proprieties, such as antimicrobial, anti-inflammatory, anticancer, etc. The aim of this study was to investigate the biological activities of a patented PL Chios mastic extract in a human small intestine mucosa model, the Caco-2 cells. PL Chios mastic extract showed no toxic effect in Caco-2 cells treated with lower concentrations (<100 μg/ml). Pro-inflammatory cytokines were not increased in Caco-2 cells and disaccharidase activity as well as sucrase–isomaltase expression were decreased at 50 μg/ml, suggesting a potential role in glycaemic control. Also paracellular permeability was reduced in Caco-2 cells and remarkably this extract induced a barrier effect useful in protecting against chemical or biological insults.

Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model / Zorzan, Maira; Collazuol, Daniela; Ribaudo, Giovanni; Ongaro, Alberto; Scaroni, Carla; Zagotto, Giuseppe; Armanini, Decio; Barollo, Susi; Galeotti, Fabio; Volpi, Nicola; Redaelli, Marco; Pezzani., Raffaele. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 54:(2019), pp. 92-97. [10.1016/j.jff.2019.01.007]

Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model

Fabio Galeotti;Nicola Volpi;
2019

Abstract

Pistacia lentiscus L. (PL) is an evergreen shrub from which it is derived a precious aromatic resin called mastic gum or mastic. This extract possesses numerous proprieties, such as antimicrobial, anti-inflammatory, anticancer, etc. The aim of this study was to investigate the biological activities of a patented PL Chios mastic extract in a human small intestine mucosa model, the Caco-2 cells. PL Chios mastic extract showed no toxic effect in Caco-2 cells treated with lower concentrations (<100 μg/ml). Pro-inflammatory cytokines were not increased in Caco-2 cells and disaccharidase activity as well as sucrase–isomaltase expression were decreased at 50 μg/ml, suggesting a potential role in glycaemic control. Also paracellular permeability was reduced in Caco-2 cells and remarkably this extract induced a barrier effect useful in protecting against chemical or biological insults.
2019
54
92
97
Biological effects and potential mechanisms of action of Pistacia lentiscus Chios mastic extract in Caco-2 cell model / Zorzan, Maira; Collazuol, Daniela; Ribaudo, Giovanni; Ongaro, Alberto; Scaroni, Carla; Zagotto, Giuseppe; Armanini, Decio; Barollo, Susi; Galeotti, Fabio; Volpi, Nicola; Redaelli, Marco; Pezzani., Raffaele. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 54:(2019), pp. 92-97. [10.1016/j.jff.2019.01.007]
Zorzan, Maira; Collazuol, Daniela; Ribaudo, Giovanni; Ongaro, Alberto; Scaroni, Carla; Zagotto, Giuseppe; Armanini, Decio; Barollo, Susi; Galeotti, Fabio; Volpi, Nicola; Redaelli, Marco; Pezzani., Raffaele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1174879
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