The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.
Drug delivery to retinal photoreceptors / Himawan, Erico; Ekström, Per; Buzgo, Matej; Gaillard, Pieter; Stefánsson, Einar; Marigo, Valeria; Loftsson, Thorsteinn; Paquet-Durand, François. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 24:8(2019), pp. 1637-1643. [10.1016/j.drudis.2019.03.004]
Drug delivery to retinal photoreceptors
Marigo, ValeriaWriting – Original Draft Preparation
;
2019
Abstract
The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.
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Himawan et al., 2019 - Drug delivery to retinal photoreceptors - acc.manuscript.pdf
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