Respiratory samples from Pneumocystis jirovecii pneumonia (PJP) cases collected at a tertiary-care university hospital in Modena were analyzed for the presence of specific polymorphisms in the mitochondrial large subunit ribosomal RNA (mtLSU-rRNA). Retrospectively, 57 cases were selected in a six-year period and 34 out of the 57 processed BAL samples returned PCR positive results, thus allowing further molecular analysis. The following P.jirovecii genotype distribution was observed: genotype 3 (50%), genotype 2 (23%), genotype 1 (18%), genotypes 1 or 4 (9%). These data add novel insights on P.jirovecii epidemiology, investigating a previously unstudied area of Northern Italy. A peculiar local distribution is highlighted with respect to other areas within the national panorama, thus encouraging further in-depth studies in an attempt to better understand the overall situation concerning P.jirovecii genotype circulation.

Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy / Pini, Pietro; Orsi, Carlotta F; La Regina, Annunziata; Peppoloni, Samuele; Berrilli, Federica; Blasi, Elisabetta; Di Cave, David. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 40:3(2017), pp. 208-211.

Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy

Pini, Pietro;Orsi, Carlotta F;Peppoloni, Samuele;Blasi, Elisabetta
;
2017

Abstract

Respiratory samples from Pneumocystis jirovecii pneumonia (PJP) cases collected at a tertiary-care university hospital in Modena were analyzed for the presence of specific polymorphisms in the mitochondrial large subunit ribosomal RNA (mtLSU-rRNA). Retrospectively, 57 cases were selected in a six-year period and 34 out of the 57 processed BAL samples returned PCR positive results, thus allowing further molecular analysis. The following P.jirovecii genotype distribution was observed: genotype 3 (50%), genotype 2 (23%), genotype 1 (18%), genotypes 1 or 4 (9%). These data add novel insights on P.jirovecii epidemiology, investigating a previously unstudied area of Northern Italy. A peculiar local distribution is highlighted with respect to other areas within the national panorama, thus encouraging further in-depth studies in an attempt to better understand the overall situation concerning P.jirovecii genotype circulation.
40
3
208
211
Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy / Pini, Pietro; Orsi, Carlotta F; La Regina, Annunziata; Peppoloni, Samuele; Berrilli, Federica; Blasi, Elisabetta; Di Cave, David. - In: NEW MICROBIOLOGICA. - ISSN 1121-7138. - 40:3(2017), pp. 208-211.
Pini, Pietro; Orsi, Carlotta F; La Regina, Annunziata; Peppoloni, Samuele; Berrilli, Federica; Blasi, Elisabetta; Di Cave, David
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1173427
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