The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines / Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K; Ayre, D Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N; Baxter, Amy A; Bebawy, Mary; Beckham, Carla; Bedina Zavec, Apolonija; Benmoussa, Abderrahim; Berardi, Anna C; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borràs, Francesc E; Bosch, Steffi; Boulanger, Chantal M; Breakefield, Xandra; Breglio, Andrew M; Brennan, Meadhbh Á; Brigstock, David R; Brisson, Alain; Broekman, Marike LD; Bromberg, Jacqueline F; Bryl-Górecka, Paulina; Buch, Shilpa; Buck, Amy H; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzás, Edit I; Byrd, James Bryan; Camussi, Giovanni; Carter, David RF; Caruso, Sarah; Chamley, Lawrence W; Chang, Yu-Ting; Chaudhuri, Amrita Datta; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R; Clayton, Aled; Clerici, Stefano P; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank AW; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D’Souza-Schorey, Crislyn; Das, Saumya; de Candia, Paola; De Santana, Eliezer F; De Wever, Olivier; del Portillo, Hernando A; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R; Driedonks, Tom AP; Duarte, Filipe V; Duncan, Heather M; Eichenberger, Ramon M; Ekström, Karin; EL Andaloussi, Samir; Elie-Caille, Celine; Erdbrügger, Uta; Falcón-Pérez, Juan M; Fatima, Farah; Fish, Jason E; Flores-Bellver, Miguel; Försönits, András; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gámez-Valero, Ana; Gardiner, Chris; Gärtner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah CI; Görgens, André; Gorski, Sharon M; Greening, David W; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F; Hochberg, Fred H; Hoffmann, Karl F; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K; Jacobsen, Soren; Jay, Steven M; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M; Jones, Jennifer C; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J; Kornek, Miroslaw; Kosanović, Maja M; Kovács, Árpád Ferenc; Krämer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor V; Kusuma, Gina D; Kuypers, Sören; Laitinen, Saara; Langevin, Scott M; Languino, Lucia R; Lannigan, Joanne; Lässer, Cecilia; Laurent, Louise C; Lavieu, Gregory; Lázaro-Ibáñez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac TS; Liao, Ke; Libregts, Sten F; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Linē, Aija; Linnemannstöns, Karen; Llorente, Alicia; Lombard, Catherine A; Lorenowicz, Magdalena J; Lörincz, Ákos M; Lötvall, Jan; Lovett, Jason; Lowry, Michelle C; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R; Maas, Sybren LN; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S; Martin-Jaular, Lorena; Martinez, M Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; Mcginnis, Lynda K; Mcvey, Mark J; Meckes, David G; Meehan, Katie L; Mertens, Inge; Minciacchi, Valentina R; Möller, Andreas; Møller Jørgensen, Malene; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, François; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C; Myburgh, Kathryn H; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P; Nolte-’t Hoen, Esther NM; Noren Hooten, Nicole; O’Driscoll, Lorraine; O’Grady, Tina; O’Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A; Osteikoetxea, Xabier; Ostegaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D. Michiel; Peinado, Hector; Perut, Francesca; Pfaffl, Michael W; Phinney, Donald G; Pieters, Bartijn CH; Pink, Ryan C; Pisetsky, David S; Pogge von Strandmann, Elke; Polakovicova, Iva; Poon, Ivan KH; Powell, Bonita H; Prada, Ilaria; Pulliam, Lynn; Quesenberry, Peter; Radeghieri, Annalisa; Raffai, Robert L; Raimondo, Stefania; Rak, Janusz; Ramirez, Marcel I; Raposo, Graça; Rayyan, Morsi S; Regev-Rudzki, Neta; Ricklefs, Franz L; Robbins, Paul D; Roberts, David D; Rodrigues, Silvia C; Rohde, Eva; Rome, Sophie; Rouschop, Kasper MA; Rughetti, Aurelia; Russell, Ashley E; Saá, Paula; Sahoo, Susmita; Salas-Huenuleo, Edison; Sánchez, Catherine; Saugstad, Julie A; Saul, Meike J; Schiffelers, Raymond M; Schneider, Raphael; Schøyen, Tine Hiorth; Scott, Aaron; Shahaj, Eriomina; Sharma, Shivani; Shatnyeva, Olga; Shekari, Faezeh; Shelke, Ganesh Vilas; Shetty, Ashok K; Shiba, Kiyotaka; Siljander, Pia R-M; Silva, Andreia M; Skowronek, Agata; Snyder, Orman L; Soares, Rodrigo Pedro; Sódar, Barbara W; Soekmadji, Carolina; Sotillo, Javier; Stahl, Philip D; Stoorvogel, Willem; Stott, Shannon L; Strasser, Erwin F; Swift, Simon; Tahara, Hidetoshi; Tewari, Muneesh; Timms, Kate; Tiwari, Swasti; Tixeira, Rochelle; Tkach, Mercedes; Toh, Wei Seong; Tomasini, Richard; Torrecilhas, Ana Claudia; Tosar, Juan Pablo; Toxavidis, Vasilis; Urbanelli, Lorena; Vader, Pieter; van Balkom, Bas WM; van der Grein, Susanne G; Van Deun, Jan; van Herwijnen, Martijn JC; Van Keuren-Jensen, Kendall; van Niel, Guillaume; van Royen, Martin E; van Wijnen, Andre J; Vasconcelos, M Helena; Vechetti, Ivan J; Veit, Tiago D; Vella, Laura J; Velot, Émilie; Verweij, Frederik J; Vestad, Beate; Viñas, Jose L; Visnovitz, Tamás; Vukman, Krisztina V; Wahlgren, Jessica; Watson, Dionysios C; Wauben, Marca HM; Weaver, Alissa; Webber, Jason P; Weber, Viktoria; Wehman, Ann M; Weiss, Daniel J; Welsh, Joshua A; Wendt, Sebastian; Wheelock, Asa M; Wiener, Zoltán; Witte, Leonie; Wolfram, Joy; Xagorari, Angeliki; Xander, Patricia; Xu, Jing; Yan, Xiaomei; Yáñez-Mó, María; Yin, Hang; Yuana, Yuana; Zappulli, Valentina; Zarubova, Jana; Žėkas, Vytautas; Zhang, Jian-ye; Zhao, Zezhou; Zheng, Lei; Zheutlin, Alexander R; Zickler, Antje M; Zimmermann, Pascale; Zivkovic, Angela M; Zocco, Davide; Zuba-Surma, Ewa K. - In: JOURNAL OF EXTRACELLULAR VESICLES. - ISSN 2001-3078. - 7:1(2018), pp. ---. [10.1080/20013078.2018.1535750]

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Dominici, Massimo;
2018

Abstract

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines / Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K; Ayre, D Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N; Baxter, Amy A; Bebawy, Mary; Beckham, Carla; Bedina Zavec, Apolonija; Benmoussa, Abderrahim; Berardi, Anna C; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borràs, Francesc E; Bosch, Steffi; Boulanger, Chantal M; Breakefield, Xandra; Breglio, Andrew M; Brennan, Meadhbh Á; Brigstock, David R; Brisson, Alain; Broekman, Marike LD; Bromberg, Jacqueline F; Bryl-Górecka, Paulina; Buch, Shilpa; Buck, Amy H; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzás, Edit I; Byrd, James Bryan; Camussi, Giovanni; Carter, David RF; Caruso, Sarah; Chamley, Lawrence W; Chang, Yu-Ting; Chaudhuri, Amrita Datta; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R; Clayton, Aled; Clerici, Stefano P; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank AW; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D’Souza-Schorey, Crislyn; Das, Saumya; de Candia, Paola; De Santana, Eliezer F; De Wever, Olivier; del Portillo, Hernando A; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R; Driedonks, Tom AP; Duarte, Filipe V; Duncan, Heather M; Eichenberger, Ramon M; Ekström, Karin; EL Andaloussi, Samir; Elie-Caille, Celine; Erdbrügger, Uta; Falcón-Pérez, Juan M; Fatima, Farah; Fish, Jason E; Flores-Bellver, Miguel; Försönits, András; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gámez-Valero, Ana; Gardiner, Chris; Gärtner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah CI; Görgens, André; Gorski, Sharon M; Greening, David W; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F; Hochberg, Fred H; Hoffmann, Karl F; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K; Jacobsen, Soren; Jay, Steven M; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M; Jones, Jennifer C; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J; Kornek, Miroslaw; Kosanović, Maja M; Kovács, Árpád Ferenc; Krämer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor V; Kusuma, Gina D; Kuypers, Sören; Laitinen, Saara; Langevin, Scott M; Languino, Lucia R; Lannigan, Joanne; Lässer, Cecilia; Laurent, Louise C; Lavieu, Gregory; Lázaro-Ibáñez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac TS; Liao, Ke; Libregts, Sten F; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Linē, Aija; Linnemannstöns, Karen; Llorente, Alicia; Lombard, Catherine A; Lorenowicz, Magdalena J; Lörincz, Ákos M; Lötvall, Jan; Lovett, Jason; Lowry, Michelle C; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R; Maas, Sybren LN; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S; Martin-Jaular, Lorena; Martinez, M Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; Mcginnis, Lynda K; Mcvey, Mark J; Meckes, David G; Meehan, Katie L; Mertens, Inge; Minciacchi, Valentina R; Möller, Andreas; Møller Jørgensen, Malene; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, François; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C; Myburgh, Kathryn H; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P; Nolte-’t Hoen, Esther NM; Noren Hooten, Nicole; O’Driscoll, Lorraine; O’Grady, Tina; O’Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A; Osteikoetxea, Xabier; Ostegaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D. Michiel; Peinado, Hector; Perut, Francesca; Pfaffl, Michael W; Phinney, Donald G; Pieters, Bartijn CH; Pink, Ryan C; Pisetsky, David S; Pogge von Strandmann, Elke; Polakovicova, Iva; Poon, Ivan KH; Powell, Bonita H; Prada, Ilaria; Pulliam, Lynn; Quesenberry, Peter; Radeghieri, Annalisa; Raffai, Robert L; Raimondo, Stefania; Rak, Janusz; Ramirez, Marcel I; Raposo, Graça; Rayyan, Morsi S; Regev-Rudzki, Neta; Ricklefs, Franz L; Robbins, Paul D; Roberts, David D; Rodrigues, Silvia C; Rohde, Eva; Rome, Sophie; Rouschop, Kasper MA; Rughetti, Aurelia; Russell, Ashley E; Saá, Paula; Sahoo, Susmita; Salas-Huenuleo, Edison; Sánchez, Catherine; Saugstad, Julie A; Saul, Meike J; Schiffelers, Raymond M; Schneider, Raphael; Schøyen, Tine Hiorth; Scott, Aaron; Shahaj, Eriomina; Sharma, Shivani; Shatnyeva, Olga; Shekari, Faezeh; Shelke, Ganesh Vilas; Shetty, Ashok K; Shiba, Kiyotaka; Siljander, Pia R-M; Silva, Andreia M; Skowronek, Agata; Snyder, Orman L; Soares, Rodrigo Pedro; Sódar, Barbara W; Soekmadji, Carolina; Sotillo, Javier; Stahl, Philip D; Stoorvogel, Willem; Stott, Shannon L; Strasser, Erwin F; Swift, Simon; Tahara, Hidetoshi; Tewari, Muneesh; Timms, Kate; Tiwari, Swasti; Tixeira, Rochelle; Tkach, Mercedes; Toh, Wei Seong; Tomasini, Richard; Torrecilhas, Ana Claudia; Tosar, Juan Pablo; Toxavidis, Vasilis; Urbanelli, Lorena; Vader, Pieter; van Balkom, Bas WM; van der Grein, Susanne G; Van Deun, Jan; van Herwijnen, Martijn JC; Van Keuren-Jensen, Kendall; van Niel, Guillaume; van Royen, Martin E; van Wijnen, Andre J; Vasconcelos, M Helena; Vechetti, Ivan J; Veit, Tiago D; Vella, Laura J; Velot, Émilie; Verweij, Frederik J; Vestad, Beate; Viñas, Jose L; Visnovitz, Tamás; Vukman, Krisztina V; Wahlgren, Jessica; Watson, Dionysios C; Wauben, Marca HM; Weaver, Alissa; Webber, Jason P; Weber, Viktoria; Wehman, Ann M; Weiss, Daniel J; Welsh, Joshua A; Wendt, Sebastian; Wheelock, Asa M; Wiener, Zoltán; Witte, Leonie; Wolfram, Joy; Xagorari, Angeliki; Xander, Patricia; Xu, Jing; Yan, Xiaomei; Yáñez-Mó, María; Yin, Hang; Yuana, Yuana; Zappulli, Valentina; Zarubova, Jana; Žėkas, Vytautas; Zhang, Jian-ye; Zhao, Zezhou; Zheng, Lei; Zheutlin, Alexander R; Zickler, Antje M; Zimmermann, Pascale; Zivkovic, Angela M; Zocco, Davide; Zuba-Surma, Ewa K. - In: JOURNAL OF EXTRACELLULAR VESICLES. - ISSN 2001-3078. - 7:1(2018), pp. ---. [10.1080/20013078.2018.1535750]
Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; Arab, Tanina; Archer, Fabienne; Atkin-Smith, Georgia K; Ayre, D Craig; Bach, Jean-Marie; Bachurski, Daniel; Baharvand, Hossein; Balaj, Leonora; Baldacchino, Shawn; Bauer, Natalie N; Baxter, Amy A; Bebawy, Mary; Beckham, Carla; Bedina Zavec, Apolonija; Benmoussa, Abderrahim; Berardi, Anna C; Bergese, Paolo; Bielska, Ewa; Blenkiron, Cherie; Bobis-Wozowicz, Sylwia; Boilard, Eric; Boireau, Wilfrid; Bongiovanni, Antonella; Borràs, Francesc E; Bosch, Steffi; Boulanger, Chantal M; Breakefield, Xandra; Breglio, Andrew M; Brennan, Meadhbh Á; Brigstock, David R; Brisson, Alain; Broekman, Marike LD; Bromberg, Jacqueline F; Bryl-Górecka, Paulina; Buch, Shilpa; Buck, Amy H; Burger, Dylan; Busatto, Sara; Buschmann, Dominik; Bussolati, Benedetta; Buzás, Edit I; Byrd, James Bryan; Camussi, Giovanni; Carter, David RF; Caruso, Sarah; Chamley, Lawrence W; Chang, Yu-Ting; Chaudhuri, Amrita Datta; Chen, Chihchen; Chen, Shuai; Cheng, Lesley; Chin, Andrew R; Clayton, Aled; Clerici, Stefano P; Cocks, Alex; Cocucci, Emanuele; Coffey, Robert J; Cordeiro-da-Silva, Anabela; Couch, Yvonne; Coumans, Frank AW; Coyle, Beth; Crescitelli, Rossella; Criado, Miria Ferreira; D’Souza-Schorey, Crislyn; Das, Saumya; de Candia, Paola; De Santana, Eliezer F; De Wever, Olivier; del Portillo, Hernando A; Demaret, Tanguy; Deville, Sarah; Devitt, Andrew; Dhondt, Bert; Di Vizio, Dolores; Dieterich, Lothar C; Dolo, Vincenza; Dominguez Rubio, Ana Paula; Dominici, Massimo; Dourado, Mauricio R; Driedonks, Tom AP; Duarte, Filipe V; Duncan, Heather M; Eichenberger, Ramon M; Ekström, Karin; EL Andaloussi, Samir; Elie-Caille, Celine; Erdbrügger, Uta; Falcón-Pérez, Juan M; Fatima, Farah; Fish, Jason E; Flores-Bellver, Miguel; Försönits, András; Frelet-Barrand, Annie; Fricke, Fabia; Fuhrmann, Gregor; Gabrielsson, Susanne; Gámez-Valero, Ana; Gardiner, Chris; Gärtner, Kathrin; Gaudin, Raphael; Gho, Yong Song; Giebel, Bernd; Gilbert, Caroline; Gimona, Mario; Giusti, Ilaria; Goberdhan, Deborah CI; Görgens, André; Gorski, Sharon M; Greening, David W; Gross, Julia Christina; Gualerzi, Alice; Gupta, Gopal N; Gustafson, Dakota; Handberg, Aase; Haraszti, Reka A; Harrison, Paul; Hegyesi, Hargita; Hendrix, An; Hill, Andrew F; Hochberg, Fred H; Hoffmann, Karl F; Holder, Beth; Holthofer, Harry; Hosseinkhani, Baharak; Hu, Guoku; Huang, Yiyao; Huber, Veronica; Hunt, Stuart; Ibrahim, Ahmed Gamal-Eldin; Ikezu, Tsuneya; Inal, Jameel M; Isin, Mustafa; Ivanova, Alena; Jackson, Hannah K; Jacobsen, Soren; Jay, Steven M; Jayachandran, Muthuvel; Jenster, Guido; Jiang, Lanzhou; Johnson, Suzanne M; Jones, Jennifer C; Jong, Ambrose; Jovanovic-Talisman, Tijana; Jung, Stephanie; Kalluri, Raghu; Kano, Shin-ichi; Kaur, Sukhbir; Kawamura, Yumi; Keller, Evan T; Khamari, Delaram; Khomyakova, Elena; Khvorova, Anastasia; Kierulf, Peter; Kim, Kwang Pyo; Kislinger, Thomas; Klingeborn, Mikael; Klinke, David J; Kornek, Miroslaw; Kosanović, Maja M; Kovács, Árpád Ferenc; Krämer-Albers, Eva-Maria; Krasemann, Susanne; Krause, Mirja; Kurochkin, Igor V; Kusuma, Gina D; Kuypers, Sören; Laitinen, Saara; Langevin, Scott M; Languino, Lucia R; Lannigan, Joanne; Lässer, Cecilia; Laurent, Louise C; Lavieu, Gregory; Lázaro-Ibáñez, Elisa; Le Lay, Soazig; Lee, Myung-Shin; Lee, Yi Xin Fiona; Lemos, Debora S; Lenassi, Metka; Leszczynska, Aleksandra; Li, Isaac TS; Liao, Ke; Libregts, Sten F; Ligeti, Erzsebet; Lim, Rebecca; Lim, Sai Kiang; Linē, Aija; Linnemannstöns, Karen; Llorente, Alicia; Lombard, Catherine A; Lorenowicz, Magdalena J; Lörincz, Ákos M; Lötvall, Jan; Lovett, Jason; Lowry, Michelle C; Loyer, Xavier; Lu, Quan; Lukomska, Barbara; Lunavat, Taral R; Maas, Sybren LN; Malhi, Harmeet; Marcilla, Antonio; Mariani, Jacopo; Mariscal, Javier; Martens-Uzunova, Elena S; Martin-Jaular, Lorena; Martinez, M Carmen; Martins, Vilma Regina; Mathieu, Mathilde; Mathivanan, Suresh; Maugeri, Marco; Mcginnis, Lynda K; Mcvey, Mark J; Meckes, David G; Meehan, Katie L; Mertens, Inge; Minciacchi, Valentina R; Möller, Andreas; Møller Jørgensen, Malene; Morales-Kastresana, Aizea; Morhayim, Jess; Mullier, François; Muraca, Maurizio; Musante, Luca; Mussack, Veronika; Muth, Dillon C; Myburgh, Kathryn H; Najrana, Tanbir; Nawaz, Muhammad; Nazarenko, Irina; Nejsum, Peter; Neri, Christian; Neri, Tommaso; Nieuwland, Rienk; Nimrichter, Leonardo; Nolan, John P; Nolte-’t Hoen, Esther NM; Noren Hooten, Nicole; O’Driscoll, Lorraine; O’Grady, Tina; O’Loghlen, Ana; Ochiya, Takahiro; Olivier, Martin; Ortiz, Alberto; Ortiz, Luis A; Osteikoetxea, Xabier; Ostegaard, Ole; Ostrowski, Matias; Park, Jaesung; Pegtel, D. 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