Purpose: To investigate the feasibility and the clinical response of a stereotactic single-dose radiation treatment for liver rumors. Patients and Methods: Between April 1997 and September 1999, a stereotactic single-dose radiation treatment of 60 liver tumors (four primary tumors, 56 metastases) in 37 patients was performed. Patients were positioned in an individually shaped vacuum pillow. The applied dose was escalated from 14 to 26 Gy (reference point), with the 80% isodose surrounding the planning target volume. Median tumor size was 10 cm(3) (range, 1 to 132 cm(3)). The morbidity, clinical outcome, laboratory findings, and response as seen on computed tomography (CT) scan were evaluated. Results: Follow-up data could be obtained from 55 treated tumors (35 patients). The median follow-up period was 5.7 months (range, 1.0 to 26.1 months; mean, 9.5 months). The treatment was well tolerated by all patients. There were no major side effects. Fifty-four (98%) of 55 tumors were locally controlled after 6 weeks at the initial follow-up based on the CT findings (22 cases of stable disease, 28 partial responses, and four complete responses). After a dose-escalating and learning phase, the actuarial local tumor control rate was 81% at 18 months after therapy. A total of 12 local failures were observed during follow-up. So far, the longest local tumor control is 26.1 months. Conclusion: Stereotactic single-dose radiation therapy is a feasible method for the treatment of singular inoperable liver metastases with the potential of a high local tumor control rate and low morbidity. J Clin Oncol 19:164-170. (C) 2001 by American Society of Clinical Oncology.

Stereotactic single-dose radiation therapy of liver tumors: Results of a phase I/II trial / Herfarth, Kk; Debus, J; Lohr, F; Bahner, Ml; Rhein, B; Fritz, P; Hoss, A; Schlegel, W; Wannenmacher, Mf. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - 19:1(2001), pp. 164-170.

Stereotactic single-dose radiation therapy of liver tumors: Results of a phase I/II trial

Lohr F;
2001

Abstract

Purpose: To investigate the feasibility and the clinical response of a stereotactic single-dose radiation treatment for liver rumors. Patients and Methods: Between April 1997 and September 1999, a stereotactic single-dose radiation treatment of 60 liver tumors (four primary tumors, 56 metastases) in 37 patients was performed. Patients were positioned in an individually shaped vacuum pillow. The applied dose was escalated from 14 to 26 Gy (reference point), with the 80% isodose surrounding the planning target volume. Median tumor size was 10 cm(3) (range, 1 to 132 cm(3)). The morbidity, clinical outcome, laboratory findings, and response as seen on computed tomography (CT) scan were evaluated. Results: Follow-up data could be obtained from 55 treated tumors (35 patients). The median follow-up period was 5.7 months (range, 1.0 to 26.1 months; mean, 9.5 months). The treatment was well tolerated by all patients. There were no major side effects. Fifty-four (98%) of 55 tumors were locally controlled after 6 weeks at the initial follow-up based on the CT findings (22 cases of stable disease, 28 partial responses, and four complete responses). After a dose-escalating and learning phase, the actuarial local tumor control rate was 81% at 18 months after therapy. A total of 12 local failures were observed during follow-up. So far, the longest local tumor control is 26.1 months. Conclusion: Stereotactic single-dose radiation therapy is a feasible method for the treatment of singular inoperable liver metastases with the potential of a high local tumor control rate and low morbidity. J Clin Oncol 19:164-170. (C) 2001 by American Society of Clinical Oncology.
19
1
164
170
Stereotactic single-dose radiation therapy of liver tumors: Results of a phase I/II trial / Herfarth, Kk; Debus, J; Lohr, F; Bahner, Ml; Rhein, B; Fritz, P; Hoss, A; Schlegel, W; Wannenmacher, Mf. - In: JOURNAL OF CLINICAL ONCOLOGY. - ISSN 0732-183X. - 19:1(2001), pp. 164-170.
Herfarth, Kk; Debus, J; Lohr, F; Bahner, Ml; Rhein, B; Fritz, P; Hoss, A; Schlegel, W; Wannenmacher, Mf
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1172484
Citazioni
  • ???jsp.display-item.citation.pmc??? 99
  • Scopus 423
  • ???jsp.display-item.citation.isi??? 390
social impact