Background and purpose: Evaluation of outcome and prognostic factors in patients with brain stem glioma (BSG) following fractionated stereotactic radiotherapy (FSRT). Materials and methods: Between 1990 and 1997, we treated 41 patients with FSRT in a phase I/II trial. Median age was 24 years. Out of 36 patients with histologically proven glioma, ten had a partial tumour resection. Histology revealed low grade gliomas in 30 patients and anaplastic gliomas in six patients. A mean total dose of 54 Gy was given in daily fractions of 1.8 Gy. Median follow-up was 12 months. Results: Three patients died during FSRT. Neurological improvement was achieved in 19/38 patients. Reduction of tumour size was reported in 12/38, in 16 patients the lesion was unchanged, ten showed progression. Median time to progression was 23 months, median overall survival 40 months with an actuarial survival of 83% at 1 year, 55% at 3 years and 33% at 5 years. In 20 of 22 patients with recurrence progression was inside the target volume. Significant prognostic factors for survival were clinical and radiological response 6 weeks after FSRT. Treatment toxicity was mild. Ototoxicity occurred in one patient. Conclusions: FSRT is a feasible treatment modality for BSG with tolerable toxicity. The risk of marginal failure is low. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
|Data di pubblicazione:||2000|
|Titolo:||Fractionated stereotactic conformal radiation therapy of brain stem gliomas: outcome and prognostic factors|
|Autore/i:||Schulz-Ertner, D; Debus, J; Lohr, F; Frank, C; Hoss, A; Wannenmacher, M|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0167-8140(00)00230-9|
|Codice identificativo ISI:||WOS:000165338200014|
|Codice identificativo Scopus:||2-s2.0-0034332874|
|Codice identificativo Pubmed:||11054526|
|Citazione:||Fractionated stereotactic conformal radiation therapy of brain stem gliomas: outcome and prognostic factors / Schulz-Ertner, D; Debus, J; Lohr, F; Frank, C; Hoss, A; Wannenmacher, M. - In: RADIOTHERAPY AND ONCOLOGY. - ISSN 0167-8140. - 57:2(2000), pp. 215-223.|
|Tipologia||Articolo su rivista|
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