Long image acquisition times of 60-120 s for cone-beam CT (CBCT) limit the number of patients with lung cancer who can undergo volume image guidance under breathhold. We developed a low-dose dual-energy kilovoltage-megavoltage-cone-beam CT (kVMV-CBCT) based on a clinical treatment unit reducing imaging time to <= 15 s. Simultaneous kVMV-imaging was achieved by dedicated synchronization hardware controlling the output of the linear accelerator (linac) based on detector panel readout signals, preventing imaging artifacts from interference of the linac's MV-irradiation and panel readouts. Optimization was performed to minimize the imaging dose. Single MV-projections, reconstructed MV-CBCT images and images of simultaneous 90 degrees kV- and 90 degrees MV-CBCT (180 degrees kVMV-CBCT) were acquired with different parameters. Image quality and imaging dose were evaluated and compared to kV-imaging. Hardware-based kVMV synchronization resulted in artifact-free projections. A combined 180 degrees kVMV-CBCT scan with a total MV-dose of 5 monitor units was acquired in 15 s and with sufficient image quality. The resolution was 5-6 line pairs cm(-1) (Catphan phantom). The combined kVMV-scan dose was equivalent to a kV-radiation scan dose of similar to 33 mGy. kVMV-CBCT based on a standard linac is promising and can provide ultra-fast online volume image guidance with low imaging dose and sufficient image quality for fast and accurate patient positioning for patients with lung cancer under breathhold.
|Data di pubblicazione:||2010|
|Titolo:||Fast kilovoltage/megavoltage (kVMV) breathhold cone-beam CT for image-guided radiotherapy of lung cancer|
|Autore/i:||Wertz, H; Stsepankou, D; Blessing, M; Rossi, M; Knox, C; Brown, K; Gros, U; Boda-Heggemann, J; Walter, C; Hesser, J; Lohr, F; Wenz, F|
|Digital Object Identifier (DOI):||10.1088/0031-9155/55/15/001|
|Codice identificativo ISI:||WOS:000280115200001|
|Codice identificativo Scopus:||2-s2.0-78049432919|
|Codice identificativo Pubmed:||20616405|
|Citazione:||Fast kilovoltage/megavoltage (kVMV) breathhold cone-beam CT for image-guided radiotherapy of lung cancer / Wertz, H; Stsepankou, D; Blessing, M; Rossi, M; Knox, C; Brown, K; Gros, U; Boda-Heggemann, J; Walter, C; Hesser, J; Lohr, F; Wenz, F. - In: PHYSICS IN MEDICINE AND BIOLOGY. - ISSN 0031-9155. - 55:15(2010), pp. 4203-4217.|
|Tipologia||Articolo su rivista|
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