Purpose: To evaluate the long-term cognitive function of patients with cerebral arteriovenous malformations (AVMs) after radiosurgery. Methods and Materials: The data of 95 AVM patients were prospectively assessed up to 3 years after radiosurgery. Of these patients, 39 had a follow-up of at least 2 years. Radiosurgery was performed using a modified linear accelerator (minimal doses to the target volume 15-22 Gy, median dose 20). The neuropsychological evaluation included testing of intelligence, attention, and memory. The effect of a preexisting intracranial hemorrhage, as well as AVM occlusion, on cognitive functions was analyzed after 1 and 2 years. Results: No cognitive declines were observed during follow-up. Instead significant improvements occurred in intelligence (1 year, +6.1 IQ points; 2 years, +5.1 IQ points), memory (1 year, +18.3 percentile score; 2 years, +12.2 percentile score), and attention (1 year, +19 percentile score; 2 years, +18 percentile score). Patients without previous intracranial hemorrhage improved more than patients with intracranial hemorrhage, although this difference was not statistically significant. The role of AVM occlusion on cognitive function is not clear at present. Conclusion: Radiosurgery does not induce measurable deterioration of cognitive function in patients with cerebral AVMs. (C) 2002 Elsevier Science Inc.

Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: Prospective long-term follow-up / Steinvorth, S; Wenz, F; Wildermuth, S; Essig, M; Fuss, M; Lohr, F; Debus, K; Wannenmacher, M; Hacke, W. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - 54:5(2002), pp. 1430-1437. [10.1016/S0360-3016(02)03800-2]

Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: Prospective long-term follow-up

Lohr F;
2002

Abstract

Purpose: To evaluate the long-term cognitive function of patients with cerebral arteriovenous malformations (AVMs) after radiosurgery. Methods and Materials: The data of 95 AVM patients were prospectively assessed up to 3 years after radiosurgery. Of these patients, 39 had a follow-up of at least 2 years. Radiosurgery was performed using a modified linear accelerator (minimal doses to the target volume 15-22 Gy, median dose 20). The neuropsychological evaluation included testing of intelligence, attention, and memory. The effect of a preexisting intracranial hemorrhage, as well as AVM occlusion, on cognitive functions was analyzed after 1 and 2 years. Results: No cognitive declines were observed during follow-up. Instead significant improvements occurred in intelligence (1 year, +6.1 IQ points; 2 years, +5.1 IQ points), memory (1 year, +18.3 percentile score; 2 years, +12.2 percentile score), and attention (1 year, +19 percentile score; 2 years, +18 percentile score). Patients without previous intracranial hemorrhage improved more than patients with intracranial hemorrhage, although this difference was not statistically significant. The role of AVM occlusion on cognitive function is not clear at present. Conclusion: Radiosurgery does not induce measurable deterioration of cognitive function in patients with cerebral AVMs. (C) 2002 Elsevier Science Inc.
54
5
1430
1437
Cognitive function in patients with cerebral arteriovenous malformations after radiosurgery: Prospective long-term follow-up / Steinvorth, S; Wenz, F; Wildermuth, S; Essig, M; Fuss, M; Lohr, F; Debus, K; Wannenmacher, M; Hacke, W. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - 54:5(2002), pp. 1430-1437. [10.1016/S0360-3016(02)03800-2]
Steinvorth, S; Wenz, F; Wildermuth, S; Essig, M; Fuss, M; Lohr, F; Debus, K; Wannenmacher, M; Hacke, W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1172391
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