Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation

Grigioni, F.; Benfari, G.; Vanoverschelde, J. -L.; Tribouilloy, C.; Avierinos, J. -F.; Bursi, F.; Suri, R. M.; Guerra, F.; Pasquet, A.; Rusinaru, D.; Marcelli, E.; Theron, A.; Barbieri, A.; Michelena, H.; Lazam, S.; Szymanski, C.; Nkomo, V. T.; Capucci, A.; Thapa, P.; Enriquez-Sarano, M.; for the MIDA Investigators Clavel, M. A.; Maalouf, J.; Trojette, F.; Szymanski, C.; Touati, G.; Remadi, J. P.; Russo, A.; Biagini, E.; Pasquale, F.; Ferlito, M.; Rapezzi, C.; Savini, C.; Marinelli, G.; Pacini, D.; Gargiulo, G. D.; Di Bartolomeo, R.; Boulif, J.; de Meester, C.; El Khoury, G.; Gerber, B.; Noirhomme, P.; Vancraeynest, D.; Collard, F.; Habib, G.; Mantovani, F.; Lugli, R.; Modena, M. G.; Boriani, G.; Bacchi-Reggiani, L.

doi:10.1016/j.jacc.2018.10.067

Background: Scientific guidelines consider atrial fibrillation (AF) complicating degenerative mitral regurgitation (DMR) a debated indication for surgery. Objectives: This study analyzed the prognostic/therapeutic implications of AF at DMR diagnosis and long-term. Methods: Patients were enrolled in the MIDA (Mitral Regurgitation International Database) registry, which reported the consecutive, multicenter, international experience with DMR due to flail leaflets echocardiographically diagnosed. Results: Among 2,425 patients (age 67 ± 13 years; 71% male, 67% asymptomatic, ejection fraction 64 ± 10%), 1,646 presented at diagnosis with sinus rhythm (SR), 317 with paroxysmal AD, and 462 with persistent AF. Underlying clinical/instrumental characteristics progressively worsened from SR to paroxysmal to persistent AF. During follow-up, paroxysmal and persistent AF were associated with excess mortality (10-year survival in SR and in paroxysmal and persistent AF was 74 ± 1%, 59 ± 3%, and 46 ± 2%, respectively; p < 0.0001), that persisted 20 years post-diagnosis and independently of all baseline characteristics (p values <0.0001). Surgery (n = 1,889, repair 88%) was associated with better survival versus medical management, regardless of all baseline characteristics and rhythm (adjusted hazard ratio: 0.26; 95% confidence interval: 0.23 to 0.30; p < 0.0001) but post-surgical outcome remained affected by AF (10-year post-surgical survival in SR and in paroxysmal and persistent AF was 82 ± 1%, 70 ± 4%, and 57 ± 3%, respectively; p < 0.0001). Conclusions: AF is a frequent occurrence at DMR diagnosis. Although AF is associated with older age and more severe presentation of DMR, it is independently associated with excess mortality long-term after diagnosis. Surgery is followed by improved survival in each cardiac rhythm subset, but persistence of excess risk is observed for each type of AF. Our study indicates that detection of AF, even paroxysmal, should trigger prompt consideration for surgery.

Long-Term Implications of Atrial Fibrillation in Patients With Degenerative Mitral Regurgitation / Grigioni, F.; Benfari, G.; Vanoverschelde, J. -L.; Tribouilloy, C.; Avierinos, J. -F.; Bursi, F.; Suri, R. M.; Guerra, F.; Pasquet, A.; Rusinaru, D.; Marcelli, E.; Theron, A.; Barbieri, A.; Michelena, H.; Lazam, S.; Szymanski, C.; Nkomo, V. T.; Capucci, A.; Thapa, P.; Enriquez-Sarano, M.; for the MIDA Investigators Clavel, M. A.; Maalouf, J.; Trojette, F.; Szymanski, C.; Touati, G.; Remadi, J. P.; Russo, A.; Biagini, E.; Pasquale, F.; Ferlito, M.; Rapezzi, C.; Savini, C.; Marinelli, G.; Pacini, D.; Gargiulo, G. D.; Di Bartolomeo, R.; Boulif, J.; de Meester, C.; El Khoury, G.; Gerber, B.; Noirhomme, P.; Vancraeynest, D.; Collard, F.; Habib, G.; Mantovani, F.; Lugli, R.; Modena, M. G.; Boriani, G.; Bacchi-Reggiani, L.. - In: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. - ISSN 0735-1097. - 73:3(2019), pp. 264-274. [10.1016/j.jacc.2018.10.067]