Abstract BACKGROUND: Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing. OBJECTIVE: To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS. METHODS: We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models. DMT exposures and pregnancy outcomes were assessed. RESULTS: Of 9,098 women meeting inclusion criteria, 1,178 (13%) women recorded 1,521 pregnancies. The annualised incidence rate of pregnancy was 0.042 (95% CI 0.040, 0.045). A total of 635 (42%) reported pregnancies were conceived on DMT, increasing from 27% in 2006 to 62% in 2016. The median duration of DMT exposure during pregnancy was 30 days (IQR: 9, 50). There were a higher number of induced abortions on FDA pregnancy class C/D drugs compared with pregnancy class B and no DMT (p = 0.010); but no differences in spontaneous abortions, term or preterm births. CONCLUSIONS: We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.

Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study / Nguyen, Ai-Lan; Havrdova, Eva Kubala; Horakova, Dana; Izquierdo, Guillermo; Kalincik, Tomas; van der Walt, Anneke; Terzi, Murat; Alroughani, Raed; Duquette, Pierre; Girard, Marc; Prat, Alexandre; Boz, Cavit; Sola, Patrizia; Ferraro, Diana; Lugaresi, Alessandra; Lechner-Scott, Jeannette; Barnett, Michael; Grand'Maison, Francois; Grammond, Pierre; Ramo-Tello, Cristina; Turkoglu, Recai; McCombe, Pamela; Pucci, Eugenio; Trojano, Maria; Granella, Franco; Spitaleri, Daniele; Van Pesch, Vincent; Soysal, Aysun; Oreja-Guevara, Celia; Verheul, Freek; Vucic, Steve; Hodgkinson, Suzanne; Slee, Mark; Ampapa, Radek; Prevost, Julie; Menoyo, Jose Luis Sanchez; Skibina, Olga; Solaro, Claudio; Olascoaga, Javier; Shaw, Cameron; Madsen, Klaus Gregaard; Naidoo, Kerisha; Hyde, Robert; Butzkueven, Helmut; Jokubaitis, Vilija. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 28:(2019), pp. 235-243. [10.1016/j.msard.2019.01.003]

Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study

Ferraro, Diana;
2019

Abstract

Abstract BACKGROUND: Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing. OBJECTIVE: To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS. METHODS: We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models. DMT exposures and pregnancy outcomes were assessed. RESULTS: Of 9,098 women meeting inclusion criteria, 1,178 (13%) women recorded 1,521 pregnancies. The annualised incidence rate of pregnancy was 0.042 (95% CI 0.040, 0.045). A total of 635 (42%) reported pregnancies were conceived on DMT, increasing from 27% in 2006 to 62% in 2016. The median duration of DMT exposure during pregnancy was 30 days (IQR: 9, 50). There were a higher number of induced abortions on FDA pregnancy class C/D drugs compared with pregnancy class B and no DMT (p = 0.010); but no differences in spontaneous abortions, term or preterm births. CONCLUSIONS: We report low pregnancy incidence rates, with increasing number of pregnancies conceived on DMT over the past 12-years. The median duration of DMT exposure in pregnancy was relatively short at one month.
3-gen-2019
28
235
243
Incidence of pregnancy and disease-modifying therapy exposure trends in women with multiple sclerosis: A contemporary cohort study / Nguyen, Ai-Lan; Havrdova, Eva Kubala; Horakova, Dana; Izquierdo, Guillermo; Kalincik, Tomas; van der Walt, Anneke; Terzi, Murat; Alroughani, Raed; Duquette, Pierre; Girard, Marc; Prat, Alexandre; Boz, Cavit; Sola, Patrizia; Ferraro, Diana; Lugaresi, Alessandra; Lechner-Scott, Jeannette; Barnett, Michael; Grand'Maison, Francois; Grammond, Pierre; Ramo-Tello, Cristina; Turkoglu, Recai; McCombe, Pamela; Pucci, Eugenio; Trojano, Maria; Granella, Franco; Spitaleri, Daniele; Van Pesch, Vincent; Soysal, Aysun; Oreja-Guevara, Celia; Verheul, Freek; Vucic, Steve; Hodgkinson, Suzanne; Slee, Mark; Ampapa, Radek; Prevost, Julie; Menoyo, Jose Luis Sanchez; Skibina, Olga; Solaro, Claudio; Olascoaga, Javier; Shaw, Cameron; Madsen, Klaus Gregaard; Naidoo, Kerisha; Hyde, Robert; Butzkueven, Helmut; Jokubaitis, Vilija. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 28:(2019), pp. 235-243. [10.1016/j.msard.2019.01.003]
Nguyen, Ai-Lan; Havrdova, Eva Kubala; Horakova, Dana; Izquierdo, Guillermo; Kalincik, Tomas; van der Walt, Anneke; Terzi, Murat; Alroughani, Raed; Duquette, Pierre; Girard, Marc; Prat, Alexandre; Boz, Cavit; Sola, Patrizia; Ferraro, Diana; Lugaresi, Alessandra; Lechner-Scott, Jeannette; Barnett, Michael; Grand'Maison, Francois; Grammond, Pierre; Ramo-Tello, Cristina; Turkoglu, Recai; Mccombe, Pamela; Pucci, Eugenio; Trojano, Maria; Granella, Franco; Spitaleri, Daniele; Van Pesch, Vincent; Soysal, Aysun; Oreja-Guevara, Celia; Verheul, Freek; Vucic, Steve; Hodgkinson, Suzanne; Slee, Mark; Ampapa, Radek; Prevost, Julie; Menoyo, Jose Luis Sanchez; Skibina, Olga; Solaro, Claudio; Olascoaga, Javier; Shaw, Cameron; Madsen, Klaus Gregaard; Naidoo, Kerisha; Hyde, Robert; Butzkueven, Helmut; Jokubaitis, Vilija
File in questo prodotto:
File Dimensione Formato  
Nguyen_2019.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 729.8 kB
Formato Adobe PDF
729.8 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1171258
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 22
social impact