Portal vein thrombosis may occur in cirrhosis; nevertheless, its prevalence, and predictors are still elusive. To investigate this issue, the Italian Society of Internal Medicine undertook the ‘‘Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry’’ (PRO-LIVER). This prospective multicenter study includes consecutive cirrhotic patients undergoing Doppler ultrasound examination of the portal area to evaluate the prevalence and incidence of portal vein thrombosis over a 2-year scheduled follow-up. Seven hundred and fifty-three (68 % men; 64 ± 12 years) patients were included in the present analysis. Fifty percent of the cases were cirrhotic outpatients. Viral (44 %) etiology was predominant. Around half of the patients had a mild-severity disease according to the Child–Pugh score; hepatocellular carcinoma was present in 20 %. The prevalence of ultrasound-detected portal vein thrombosis was 17 % (n = 126); it was asymptomatic in 43 % of the cases. Notably, more than half of the portal vein thrombosis patients (n = 81) were not treated with anticoagulant therapy. Logistic step-forward multivariate analysis demonstrated that previous portal vein thrombosis (p\0.001), Child–Pugh Class B ? C (p\0.001), hepatocellular carcinoma (p = 0.01), previous upper gastrointestinal bleeding (p = 0.030) and older age (p = 0.012) were independently associated with portal vein thrombosis. Portal vein thrombosis is a frequent complication of cirrhosis, particularly in patients with moderate–severe liver failure. The apparent undertreatment of patients with portal vein thrombosis is a matter of concern and debate, which should be addressed by planning interventional trials especially with newer oral anticoagulants

Portal vein thrombosis relevance on liver cirrhosis: Italina Venous Thrombotic Events Registry / Violi, Francesco; Gino Corazza, Roberto; Hugh Caldwell, Stephen; Perticone, Francesco; Gatta, Angelo; Angelico, Mario; Farcomeni, Alessio; Masotti, Michela; Napoleone, Laura; Vestri, Annarita; Raparelli, Valeria; Basili, Stefania; Ventura, Paolo; Collaborators, Pro-Liver. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - 11(2016), pp. 1059-1066. [10.1007/s11739-016-1416-8]

Portal vein thrombosis relevance on liver cirrhosis: Italina Venous Thrombotic Events Registry

Paolo Ventura
Membro del Collaboration Group
;
2016

Abstract

Portal vein thrombosis may occur in cirrhosis; nevertheless, its prevalence, and predictors are still elusive. To investigate this issue, the Italian Society of Internal Medicine undertook the ‘‘Portal vein thrombosis Relevance On Liver cirrhosis: Italian Venous thrombotic Events Registry’’ (PRO-LIVER). This prospective multicenter study includes consecutive cirrhotic patients undergoing Doppler ultrasound examination of the portal area to evaluate the prevalence and incidence of portal vein thrombosis over a 2-year scheduled follow-up. Seven hundred and fifty-three (68 % men; 64 ± 12 years) patients were included in the present analysis. Fifty percent of the cases were cirrhotic outpatients. Viral (44 %) etiology was predominant. Around half of the patients had a mild-severity disease according to the Child–Pugh score; hepatocellular carcinoma was present in 20 %. The prevalence of ultrasound-detected portal vein thrombosis was 17 % (n = 126); it was asymptomatic in 43 % of the cases. Notably, more than half of the portal vein thrombosis patients (n = 81) were not treated with anticoagulant therapy. Logistic step-forward multivariate analysis demonstrated that previous portal vein thrombosis (p\0.001), Child–Pugh Class B ? C (p\0.001), hepatocellular carcinoma (p = 0.01), previous upper gastrointestinal bleeding (p = 0.030) and older age (p = 0.012) were independently associated with portal vein thrombosis. Portal vein thrombosis is a frequent complication of cirrhosis, particularly in patients with moderate–severe liver failure. The apparent undertreatment of patients with portal vein thrombosis is a matter of concern and debate, which should be addressed by planning interventional trials especially with newer oral anticoagulants
30-mar-2016
11
1059
1066
Portal vein thrombosis relevance on liver cirrhosis: Italina Venous Thrombotic Events Registry / Violi, Francesco; Gino Corazza, Roberto; Hugh Caldwell, Stephen; Perticone, Francesco; Gatta, Angelo; Angelico, Mario; Farcomeni, Alessio; Masotti, Michela; Napoleone, Laura; Vestri, Annarita; Raparelli, Valeria; Basili, Stefania; Ventura, Paolo; Collaborators, Pro-Liver. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1970-9366. - 11(2016), pp. 1059-1066. [10.1007/s11739-016-1416-8]
Violi, Francesco; Gino Corazza, Roberto; Hugh Caldwell, Stephen; Perticone, Francesco; Gatta, Angelo; Angelico, Mario; Farcomeni, Alessio; Masotti, Michela; Napoleone, Laura; Vestri, Annarita; Raparelli, Valeria; Basili, Stefania; Ventura, Paolo; Collaborators, Pro-Liver
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1170562
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