TOBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease. METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures. RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP. CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study / Sebastiani, Marco; Triantafyllias, Konstantinos; Manfredi, Andreina; González-Gay, Miguel Angel; Palmou-Fontana, Natalia; Cassone, Giulia; Drott, Ulrich; Delbrück, Christiane; Rojas-Serrano, Jorge; Bertolazzi, Chiara; Nuño, Laura; Giannini, Margherita; Iannone, Florenzo; Vicente, Esther F; Castañeda, Santos; Selva-O'Callaghan, Albert; Araguas, Ernesto Trallero; Emmi, Giacomo; Iuliano, Annamaria; Bauhammer, Jutta; Miehle, Nikolaus; Parisi, Simone; Cavagna, Lorenzo; Codullo, Veronica; Montecucco, Carlomaurizio; Lopez-Longo, Francisco Javier; Martínez-Barrio, Julia; Nieto-González, Juan Carlos; Vichi, Silvia; Confalonieri, Marco; Tomietto, Paola; Bergner, Raoul; Sulli, Alberto; Bonella, Francesco; Furini, Federica; Scirè, Carlo Alberto; Bortoluzzi, Alessandra; Specker, Christof; Barsotti, Simone; Neri, Rossella; Mosca, Marta; Caproni, Marzia; Weinmann-Menke, Julia; Schwarting, Andreas; Smith, Vanessa; Cutolo, Maurizio. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 46:3(2019), pp. 279-284. [10.3899/jrheum.180355]

Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study

Sebastiani, Marco
;
Manfredi, Andreina;Cassone, Giulia;
2019

Abstract

TOBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease. METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures. RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP. CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.
1-mar-2019
46
3
279
284
Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations: Results of a Multicenter International Study / Sebastiani, Marco; Triantafyllias, Konstantinos; Manfredi, Andreina; González-Gay, Miguel Angel; Palmou-Fontana, Natalia; Cassone, Giulia; Drott, Ulrich; Delbrück, Christiane; Rojas-Serrano, Jorge; Bertolazzi, Chiara; Nuño, Laura; Giannini, Margherita; Iannone, Florenzo; Vicente, Esther F; Castañeda, Santos; Selva-O'Callaghan, Albert; Araguas, Ernesto Trallero; Emmi, Giacomo; Iuliano, Annamaria; Bauhammer, Jutta; Miehle, Nikolaus; Parisi, Simone; Cavagna, Lorenzo; Codullo, Veronica; Montecucco, Carlomaurizio; Lopez-Longo, Francisco Javier; Martínez-Barrio, Julia; Nieto-González, Juan Carlos; Vichi, Silvia; Confalonieri, Marco; Tomietto, Paola; Bergner, Raoul; Sulli, Alberto; Bonella, Francesco; Furini, Federica; Scirè, Carlo Alberto; Bortoluzzi, Alessandra; Specker, Christof; Barsotti, Simone; Neri, Rossella; Mosca, Marta; Caproni, Marzia; Weinmann-Menke, Julia; Schwarting, Andreas; Smith, Vanessa; Cutolo, Maurizio. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 46:3(2019), pp. 279-284. [10.3899/jrheum.180355]
Sebastiani, Marco; Triantafyllias, Konstantinos; Manfredi, Andreina; González-Gay, Miguel Angel; Palmou-Fontana, Natalia; Cassone, Giulia; Drott, Ulrich; Delbrück, Christiane; Rojas-Serrano, Jorge; Bertolazzi, Chiara; Nuño, Laura; Giannini, Margherita; Iannone, Florenzo; Vicente, Esther F; Castañeda, Santos; Selva-O'Callaghan, Albert; Araguas, Ernesto Trallero; Emmi, Giacomo; Iuliano, Annamaria; Bauhammer, Jutta; Miehle, Nikolaus; Parisi, Simone; Cavagna, Lorenzo; Codullo, Veronica; Montecucco, Carlomaurizio; Lopez-Longo, Francisco Javier; Martínez-Barrio, Julia; Nieto-González, Juan Carlos; Vichi, Silvia; Confalonieri, Marco; Tomietto, Paola; Bergner, Raoul; Sulli, Alberto; Bonella, Francesco; Furini, Federica; Scirè, Carlo Alberto; Bortoluzzi, Alessandra; Specker, Christof; Barsotti, Simone; Neri, Rossella; Mosca, Marta; Caproni, Marzia; Weinmann-Menke, Julia; Schwarting, Andreas; Smith, Vanessa; Cutolo, Maurizio
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