A novel fully organic bioelectronic device is presented and validated as electronic transducer and current stimulator for brain implants. The device integrates polymeric electrodes made of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) on paper thin foils, resulting in a high surface-to-volume ratio architecture that exhibits high sensitivity to interfacial ionic transport phenomena. The prototyping technique herein presented yields devices for the bidirectional communication with biological systems whose dimensionality can be controlled according to the desired application. Transduction of ultra-low local-field potentials and delivery of voltage pulse-trains alike those used in deep-brain stimulation are herein assessed, paving the way towards novel theranostic strategies for the treatment of Parkinson's Disease and other severe neurodegenerative and/or traumatic pathologies of the central nervous system.

Exploiting interfacial phenomena in organic bioelectronics: Conformable devices for bidirectional communication with living systems / Di Lauro, Michele; Benaglia, Simone; Berto, Marcello; Bortolotti, Carlo A.; Zoli, Michele; Biscarini, Fabio. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 168:(2018), pp. 143-147. [10.1016/j.colsurfb.2018.03.022]

Exploiting interfacial phenomena in organic bioelectronics: Conformable devices for bidirectional communication with living systems

Di Lauro, Michele;BENAGLIA, SIMONE;Berto, Marcello;Bortolotti, Carlo A.;Zoli, Michele;Biscarini, Fabio
2018

Abstract

A novel fully organic bioelectronic device is presented and validated as electronic transducer and current stimulator for brain implants. The device integrates polymeric electrodes made of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) on paper thin foils, resulting in a high surface-to-volume ratio architecture that exhibits high sensitivity to interfacial ionic transport phenomena. The prototyping technique herein presented yields devices for the bidirectional communication with biological systems whose dimensionality can be controlled according to the desired application. Transduction of ultra-low local-field potentials and delivery of voltage pulse-trains alike those used in deep-brain stimulation are herein assessed, paving the way towards novel theranostic strategies for the treatment of Parkinson's Disease and other severe neurodegenerative and/or traumatic pathologies of the central nervous system.
2018
19-mar-2018
168
143
147
Exploiting interfacial phenomena in organic bioelectronics: Conformable devices for bidirectional communication with living systems / Di Lauro, Michele; Benaglia, Simone; Berto, Marcello; Bortolotti, Carlo A.; Zoli, Michele; Biscarini, Fabio. - In: COLLOIDS AND SURFACES. B, BIOINTERFACES. - ISSN 0927-7765. - 168:(2018), pp. 143-147. [10.1016/j.colsurfb.2018.03.022]
Di Lauro, Michele; Benaglia, Simone; Berto, Marcello; Bortolotti, Carlo A.; Zoli, Michele; Biscarini, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1169986
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