EnglishMesalazine (5-ASA) is an aminosalicylate anti-inflammatory drug capable of inducing m-protocadherin, a protein expressed by colorectal epithelial cells that is downregulated upon malignant transformation. Treatment with 5-ASA restores m-protocadherin expression and promotes the sequestration of b-catenin to the plasma membrane. Here, we show that 5-ASA–induced m-protocadherin expression is directly regulated by the KLF4 transcription factor. In addition, we suggest the existence of a dual mechanism whereby 5-ASA–mediated b-catenin inhibition is caused by m-protocadherin–dependent sequestration of b-catenin to the plasma membrane and by the direct binding of KLF4 to b-catenin. In addition, we found that 5-ASA treatment suppresses the expression of miR-130a and miR-135b, which target KLF4 mRNA, raising the possibility that this mechanism is involved in the increased expression of KLF4 induced by 5-ASA.
| Data di pubblicazione: | 2018 |
| Titolo: | KLF4 mediates the effect of 5-ASA on the b-catenin pathway in colon cancer cells |
| Autore/i: | Parenti, Sandra; Montorsi, Lucia; Fantini, Sebastian; Mammoli, Fabiana; Gemelli, Claudia; Atene, Claudio Giacinto; Losi, Lorena; Frassineti, Chiara; Calabretta, Bruno; Tagliafico, Enrico; Ferrari, Sergio; Zanocco-Marani, Tommaso; Grande, Alexis |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | 10.1158/1940-6207.CAPR-17-0382 |
| Rivista: | |
| Volume: | 11 |
| Fascicolo: | 8 |
| Pagina iniziale: | 503 |
| Pagina finale: | 510 |
| Codice identificativo ISI: | WOS:000440815800006 |
| Codice identificativo Scopus: | 2-s2.0-85050970283 |
| Codice identificativo Pubmed: | 29794245 |
| Citazione: | KLF4 mediates the effect of 5-ASA on the b-catenin pathway in colon cancer cells / Parenti, Sandra; Montorsi, Lucia; Fantini, Sebastian; Mammoli, Fabiana; Gemelli, Claudia; Atene, Claudio Giacinto; Losi, Lorena; Frassineti, Chiara; Calabretta, Bruno; Tagliafico, Enrico; Ferrari, Sergio; Zanocco-Marani, Tommaso; Grande, Alexis. - In: CANCER PREVENTION RESEARCH. - ISSN 1940-6207. - 11:8(2018), pp. 503-510. |
| Tipologia | Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | |
|---|---|---|---|
| 503.full.pdf | Articolo | Versione editoriale | Open Access Visualizza/Apri |
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2019