Background: The long-term effectiveness of drug eluting stents (DESs) in a real-world setting of female patients is currently unclear. Methods and results: We analyzed long-term follow-up (up to 3 years) data from all female patients with de novo lesions enrolled in a prospective web-based multicenter registry (REAL Registry; study period, July 2002-June 2006) including all 15 hospitals performing PCI in the Emilia-Romagna region of Italy. Among the 3549 women without ST elevation myocardial infarction, 2434 were treated with BMSs alone and 1115 with DESs alone. At 3 years, use of DESs was associated with a lower propensity score adjusted incidence of MACE [cardiac mortality, non-fatal myocardial infarction and target vessel revascularization (TVR); 19.5% vs. 24.4%; HR 0.75, p = 0.006)] and TVR (11.6% vs. 15.6%; HR 0.68, p = 0.004) compared with BMSs. No difference was apparent in terms of adjusted 3-year cardiac mortality or myocardial infarction. Nevertheless, after the first 6 months of follow-up, a non significantly increased risk of myocardial infarction and stent thrombosis was found in the DES group. Conclusions: In this real-world female registry, the use of DESs was associated with a 3-year reduction of TVR and MACE in comparison with the use of BMSs. However, the observed (non-significant) increment of late AMI makes performing larger studies to clarify the long-term safety of DESs mandatory. © 2009 Elsevier Ireland Ltd.

Long-term clinical outcomes after drug eluting stent implantation in women with de novo coronary lesions: Results from the REAL (REgistro Regionale AngiopLastiche Emilia-Romagna) multicenter registry / Ortolani, Paolo; Solinas, Emilia; Guastaroba, Paolo; Casella, Gianni; Manari, Antonio; Piovaccari, Giancarlo; Balducelli, Marco; Tondi, Stefano; Percoco, Gianfranco; Tarantino, Fabio; Passerini, Francesco; Rossi, Rosario; Vignali, Luigi; De Palma, Rossana; Grilli, Roberto; Marzocchi, Antonio. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 149:1(2011), pp. 55-62. [10.1016/j.ijcard.2009.11.044]

Long-term clinical outcomes after drug eluting stent implantation in women with de novo coronary lesions: Results from the REAL (REgistro Regionale AngiopLastiche Emilia-Romagna) multicenter registry

Rossi, Rosario;Grilli, Roberto;
2011

Abstract

Background: The long-term effectiveness of drug eluting stents (DESs) in a real-world setting of female patients is currently unclear. Methods and results: We analyzed long-term follow-up (up to 3 years) data from all female patients with de novo lesions enrolled in a prospective web-based multicenter registry (REAL Registry; study period, July 2002-June 2006) including all 15 hospitals performing PCI in the Emilia-Romagna region of Italy. Among the 3549 women without ST elevation myocardial infarction, 2434 were treated with BMSs alone and 1115 with DESs alone. At 3 years, use of DESs was associated with a lower propensity score adjusted incidence of MACE [cardiac mortality, non-fatal myocardial infarction and target vessel revascularization (TVR); 19.5% vs. 24.4%; HR 0.75, p = 0.006)] and TVR (11.6% vs. 15.6%; HR 0.68, p = 0.004) compared with BMSs. No difference was apparent in terms of adjusted 3-year cardiac mortality or myocardial infarction. Nevertheless, after the first 6 months of follow-up, a non significantly increased risk of myocardial infarction and stent thrombosis was found in the DES group. Conclusions: In this real-world female registry, the use of DESs was associated with a 3-year reduction of TVR and MACE in comparison with the use of BMSs. However, the observed (non-significant) increment of late AMI makes performing larger studies to clarify the long-term safety of DESs mandatory. © 2009 Elsevier Ireland Ltd.
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Long-term clinical outcomes after drug eluting stent implantation in women with de novo coronary lesions: Results from the REAL (REgistro Regionale AngiopLastiche Emilia-Romagna) multicenter registry / Ortolani, Paolo; Solinas, Emilia; Guastaroba, Paolo; Casella, Gianni; Manari, Antonio; Piovaccari, Giancarlo; Balducelli, Marco; Tondi, Stefano; Percoco, Gianfranco; Tarantino, Fabio; Passerini, Francesco; Rossi, Rosario; Vignali, Luigi; De Palma, Rossana; Grilli, Roberto; Marzocchi, Antonio. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 149:1(2011), pp. 55-62. [10.1016/j.ijcard.2009.11.044]
Ortolani, Paolo; Solinas, Emilia; Guastaroba, Paolo; Casella, Gianni; Manari, Antonio; Piovaccari, Giancarlo; Balducelli, Marco; Tondi, Stefano; Percoco, Gianfranco; Tarantino, Fabio; Passerini, Francesco; Rossi, Rosario; Vignali, Luigi; De Palma, Rossana; Grilli, Roberto; Marzocchi, Antonio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1168501
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