Neonatal hypoxic-ischemic encephalopathy is still a significant cause of neonatal death and neurodevelopmental disabilities, such as cerebral palsy, mental delay, and epilepsy. After the introduction of therapeutic hypothermia, the prognosis of hypoxic-ischemic encephalopathy has improved, with reduction of death and disabilities. However, few studies evaluated whether hypothermia affects rate and severity of post-neonatal epilepsy. We evaluated rates, characteristics and prognostic markers of post-neonatal epilepsy in infants with moderate to severe hypoxic-ischemic encephalopathy treated or not with therapeutic hypothermia.
Brain cooling reduces the risk of post-neonatal epilepsy in newborns affected by moderate to severe hypoxic-ischemic encephalopathy / Lugli, Licia; Balestri, Eleonora; Berardi, Alberto; Guidotti, Isotta; Cavalleri, Francesca; Todeschini, Alessandra; Pugliese, Marisa; Muttini Della Casa, Elisa; Lucaccioni, Laura; Ferrari, Fabrizio. - In: MINERVA PEDIATRICS. - ISSN 2724-5780. - 73:2(2021), pp. 150-158. [10.23736/S2724-5276.18.05224-6]