Background: Human exposure to phthalates, endocrine disruptors ad reproductive toxicants, is ubiquitous because of their extensive use as plasticizers. Breast milk is the optimal source of nutrition for newborns, however, it can be a source of exposure to several environmental contaminants, Including phthalates. Up to date limited information exists on lactational exposure to phthalates and their metabolites in Italy: the aim of this study, therefore, was to determine the levels of 8 different phthalates diesters and monoesters in breast milk of women living in Modena, Italy, and to investigate the relationship with women's diet and other habits.Methods: 130 women (mean age: 33; range: 19 - 45 years) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources exposure to phthalates. After solid extraction, samples were analysed by triple Quad LC/MS Mass Spectrometry.Results: Phthalate diesters, due to their metabolic degradation, resulted almost undetectable. Phthalate monoesters appeared more widespread. Among them, mono-isononylphthalate (MiNP) was detected in 125 breast samples (mean: 1.63 +2.71; range: 0.10 - 18.4 µg/l) and mono-ethylphthalate (MEP) in 106 samples (mean: 2.35 + 7.36; range: 0.04 - 69.0 µg/l). Their levels appeared higher in lactating women more frequently using cosmetics or consuming food and beverages preserved in plastic containers. Differences, however, were not statistically significant. Further, levels appeared well below the daily intake levels established by the European Food Safety Authority (EFSA).Conclusions: Although a number of phthalate monoesters were detected in maternal breast milk, their concentrations tended to be lower than those reported in other international studies and the values recommend by EFSA. Human milk represent a unique nourishment for infants in a crucial period of their life: its use should not be discouraged.
Lactational Exposure to Phthalates: Preliminary Results from an Italian Cross-Sectional Study / Righi, Elena; Fantuzzi, Guglielmina; Predieri, Guerrino; Pinetti, Diego; Francesca, Faggioli; Scelsa, Francesca; Bargellini, Annalisa. - In: ENVIRONMENTAL HEALTH PERSPECTIVES. - ISSN 1552-9924. - ISEE CONFERENCE ABSTRACTS volume 2018:issue 1(2018), pp. 1844-1844. (Intervento presentato al convegno 2018 Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE 2018) “Addressing Complex Local and Global Issues in Environmental Exposure and Health”. tenutosi a Ottawa, Ontario, Canada nel AUGUST 26-30, 2018).
Lactational Exposure to Phthalates: Preliminary Results from an Italian Cross-Sectional Study
Elena Righi
;Guglielmina Fantuzzi;Guerrino Predieri;Diego Pinetti;Scelsa, Francesca;Annalisa Bargellini
2018
Abstract
Background: Human exposure to phthalates, endocrine disruptors ad reproductive toxicants, is ubiquitous because of their extensive use as plasticizers. Breast milk is the optimal source of nutrition for newborns, however, it can be a source of exposure to several environmental contaminants, Including phthalates. Up to date limited information exists on lactational exposure to phthalates and their metabolites in Italy: the aim of this study, therefore, was to determine the levels of 8 different phthalates diesters and monoesters in breast milk of women living in Modena, Italy, and to investigate the relationship with women's diet and other habits.Methods: 130 women (mean age: 33; range: 19 - 45 years) provided a sample of breast milk (30-40 days postpartum) and filled in a questionnaire on personal data and on potential sources exposure to phthalates. After solid extraction, samples were analysed by triple Quad LC/MS Mass Spectrometry.Results: Phthalate diesters, due to their metabolic degradation, resulted almost undetectable. Phthalate monoesters appeared more widespread. Among them, mono-isononylphthalate (MiNP) was detected in 125 breast samples (mean: 1.63 +2.71; range: 0.10 - 18.4 µg/l) and mono-ethylphthalate (MEP) in 106 samples (mean: 2.35 + 7.36; range: 0.04 - 69.0 µg/l). Their levels appeared higher in lactating women more frequently using cosmetics or consuming food and beverages preserved in plastic containers. Differences, however, were not statistically significant. Further, levels appeared well below the daily intake levels established by the European Food Safety Authority (EFSA).Conclusions: Although a number of phthalate monoesters were detected in maternal breast milk, their concentrations tended to be lower than those reported in other international studies and the values recommend by EFSA. Human milk represent a unique nourishment for infants in a crucial period of their life: its use should not be discouraged.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
