A 64 years-old woman presented subacute onset distal paraesthesia concurrently with cold-induced urticaria, a rare form of physical urticaria. Both the disturbances developed a fortnight after an upper respiratory tract infection. EMG confirmed an exclusively sensory polyneuropathy, with prolongation of distal latencies and reduction of amplitudes. Anti-GQ1b and anti-GT1a antigangliosides antibodies were found in serum. The clinical workout included CSF analysis, cryoglobulin and paraprotein search, neurotropic infective agents, neoplastic markers and extensive autoimmune disease antibodies analysis, all of which resulted negative. Intravenous immunoglobulins were administered, leading to progressive resolution of the sensory disturbance, while a combination of steroid and anti-histaminics treatment was used for the urticaria. The positivity for anti-ganglioside search with an EMG pattern characterized by a mixture of demyelinating and axonal features may suggest a nodo-paranodopathy at early stages. This is the first case of an association between an acute sensory neuropathy and cold urticaria, two immune mediated conditions apparently due to very different hypersensitivity pathways. A proposed mechanism for the co-occurence of these two conditions is presented, whereas this case expands the clinical spectrum of autoimmune diseases associated with anti-GQ1b and anti-GT1a antibodies.
Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria / Zucchi, Elisabetta; Cavallieri, Francesco; Giovannini, Giada; Antonelli, Francesca; Mascia, Maria Teresa; Bedin, Roberta; Mandrioli, Jessica. - In: JOURNAL OF CLINICAL NEUROSCIENCE. - ISSN 0967-5868. - 56(2018), pp. 175-177.
Data di pubblicazione: | 2018 |
Data di prima pubblicazione: | 6-lug-2018 |
Titolo: | Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria |
Autore/i: | Zucchi, Elisabetta; Cavallieri, Francesco; Giovannini, Giada; Antonelli, Francesca; Mascia, Maria Teresa; Bedin, Roberta; Mandrioli, Jessica |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jocn.2018.06.056 |
Rivista: | |
Volume: | 56 |
Pagina iniziale: | 175 |
Pagina finale: | 177 |
Codice identificativo ISI: | WOS:000449238200033 |
Codice identificativo Scopus: | 2-s2.0-85049420360 |
Codice identificativo Pubmed: | 30318072 |
Citazione: | Post-infectious sensory neuropathy with anti-GT1a and GQ1b antibodies associated with cold urticaria / Zucchi, Elisabetta; Cavallieri, Francesco; Giovannini, Giada; Antonelli, Francesca; Mascia, Maria Teresa; Bedin, Roberta; Mandrioli, Jessica. - In: JOURNAL OF CLINICAL NEUROSCIENCE. - ISSN 0967-5868. - 56(2018), pp. 175-177. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
1-s2.0-S0967586818305228-main.pdf | Versione dell'editore (versione pubblicata) | Administrator Richiedi una copia |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris