Patients presenting with upper motor neuron (UMN) signs may widely diverge in prognosis, ranging from amyotrophic lateral sclerosis (ALS) to primary lateral sclerosis (PLS) and hereditary spastic paraplegia (hSP). Neurofilaments are emerging as potential diagnostic and prognostic biomarkers for ALS, but the diagnosis of UMN syndromes still relies mostly on clinical long-term observation and on familiarity or genetic confirmation.
Cerebrospinal Fluid Neurofilaments May Discriminate Upper Motor Neuron Syndromes: A Pilot Study / Zucchi, Elisabetta; Bedin, Roberta; Fasano, Antonio; Fini, Nicola; Gessani, Annalisa; Vinceti, Marco; Mandrioli, Jessica. - In: NEURODEGENERATIVE DISEASES. - ISSN 1660-2854. - 18:5-6(2018), pp. 255-261. [10.1159/000493986]
Cerebrospinal Fluid Neurofilaments May Discriminate Upper Motor Neuron Syndromes: A Pilot Study
Zucchi, Elisabetta;Bedin, Roberta;FASANO, ANTONIO;Vinceti, Marco;Mandrioli, Jessica
2018
Abstract
Patients presenting with upper motor neuron (UMN) signs may widely diverge in prognosis, ranging from amyotrophic lateral sclerosis (ALS) to primary lateral sclerosis (PLS) and hereditary spastic paraplegia (hSP). Neurofilaments are emerging as potential diagnostic and prognostic biomarkers for ALS, but the diagnosis of UMN syndromes still relies mostly on clinical long-term observation and on familiarity or genetic confirmation.
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