Background/Aim: Seminal plasma cfDNA (scfDNA) was recently proposed as a novel PCa biomarker. Our aim was to evaluate whether scfDNA could discriminate PCa from benign prostate hyperplasia (BPH) patients. Patients and Methods: A cohort of 43 patients (18 and 25 pathology proven PCa and BPH patients), and 13 healthy age-matched control subjects were enrolled. scfDNA quantification was performed. Data were analyzed through ANOVA testing. Results: Average scfDNA concentrations were 1,407.83 ng/μl, 128.13 ng/μl and 78.09 ng/μl for PCa patients, BPH patients and healthy subjects, respectively. Statistical analysis showed a significant difference among the groups, allowing for distinction of patients with optimal accuracy. A cut-off level of 450 ng/μl scfDNA was identified for the differentiation of PCa and BPH patients. Conclusion: scfDNA concentrations are significantly different between PCa patients and BPH patients. scfDNA is a promising biomarker with several applications in PCa diagnosis, screening programs and therapeutic monitoring.
Seminal cell free DNA concentration levels discriminate between prostate cancer and benign prostatic hyperplasia / Ponti, Giovanni; Maccaferri, Monia; Micali, Salvatore; Manfredini, Marco; Milandri, Riccardo; Bianchi, Giampaolo; Pellacani, Giovanni; Kaleci, Shaniko; Chester, Johanna; Conti, Andrea; Prete, Chiara Del; Tomasi, Aldo. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 38:9(2018), pp. 5121-5125.
Data di pubblicazione: | 2018 |
Titolo: | Seminal cell free DNA concentration levels discriminate between prostate cancer and benign prostatic hyperplasia |
Autore/i: | Ponti, Giovanni; Maccaferri, Monia; Micali, Salvatore; Manfredini, Marco; Milandri, Riccardo; Bianchi, Giampaolo; Pellacani, Giovanni; Kaleci, Shaniko; Chester, Johanna; Conti, Andrea; Prete, Chiara Del; Tomasi, Aldo |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.21873/anticanres.12833 |
Rivista: | |
Volume: | 38 |
Fascicolo: | 9 |
Pagina iniziale: | 5121 |
Pagina finale: | 5125 |
Codice identificativo ISI: | WOS:000449957600019 |
Codice identificativo Scopus: | 2-s2.0-85053020348 |
Codice identificativo Pubmed: | 30194158 |
Citazione: | Seminal cell free DNA concentration levels discriminate between prostate cancer and benign prostatic hyperplasia / Ponti, Giovanni; Maccaferri, Monia; Micali, Salvatore; Manfredini, Marco; Milandri, Riccardo; Bianchi, Giampaolo; Pellacani, Giovanni; Kaleci, Shaniko; Chester, Johanna; Conti, Andrea; Prete, Chiara Del; Tomasi, Aldo. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 38:9(2018), pp. 5121-5125. |
Tipologia | Articolo su rivista |
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