Kidney transplantation is a safe and effective option for HIV-positive (HIV+) patients. We conducted a retrospective study on HIV+ kidney transplant recipients who underwent transplantation from March 2008 to September 2016.Inclusion criteria for transplantation were CD4þ T-cell count 200 per mm3 and undetectable HIV load. The current study reports the outcome of 19 HIV+ recipients, mostly of Caucasian origin (79%) with a median age of 50 years (interquartile range [IQR], 42–52), who were followed up for a median period of 2.4 years (IQR, 1.2–4.6) after transplantation. Compared with HIV-negative (HIV-) controls, HIV+ recipients had similar one- and three-year graft and patient survival, but significantly lower five-year patient survival (P¼0.03). The differences in graft outcome became less evident with the analysis of death-censored graft survival rates. Cumulative incidence of allograft rejection at one year was 32.9%. Rates of infections were not particularly elevated and HIV replication remained well controlled in all but one patient. A high prevalence of metabolic and endocrine complications (68%) was reported after transplantation. Further studies are needed to evaluate long-term outcomes of HIV+ recipients who underwent kidney transplantation.

Clinical outcome of kidney transplantation in HIV-infected recipients: a retrospective study / Alfano, G; Mori, G; Fontana, F; Dolci, G; Baisi, A; Ligabue, G; Ferrari, A; Solazzo, A; Franceschini, E; Guaradi, G; Mussini, C; Cappelli, G.. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - (2018), pp. 1-11. [10.1177/0956462418779659]

Clinical outcome of kidney transplantation in HIV-infected recipients: a retrospective study

Alfano G;Mori G;Fontana F;Dolci G;Baisi A;Ligabue G;Ferrari A;Solazzo A;Franceschini E;Mussini C;Cappelli G.
2018

Abstract

Kidney transplantation is a safe and effective option for HIV-positive (HIV+) patients. We conducted a retrospective study on HIV+ kidney transplant recipients who underwent transplantation from March 2008 to September 2016.Inclusion criteria for transplantation were CD4þ T-cell count 200 per mm3 and undetectable HIV load. The current study reports the outcome of 19 HIV+ recipients, mostly of Caucasian origin (79%) with a median age of 50 years (interquartile range [IQR], 42–52), who were followed up for a median period of 2.4 years (IQR, 1.2–4.6) after transplantation. Compared with HIV-negative (HIV-) controls, HIV+ recipients had similar one- and three-year graft and patient survival, but significantly lower five-year patient survival (P¼0.03). The differences in graft outcome became less evident with the analysis of death-censored graft survival rates. Cumulative incidence of allograft rejection at one year was 32.9%. Rates of infections were not particularly elevated and HIV replication remained well controlled in all but one patient. A high prevalence of metabolic and endocrine complications (68%) was reported after transplantation. Further studies are needed to evaluate long-term outcomes of HIV+ recipients who underwent kidney transplantation.
10-lug-2018
1
11
Clinical outcome of kidney transplantation in HIV-infected recipients: a retrospective study / Alfano, G; Mori, G; Fontana, F; Dolci, G; Baisi, A; Ligabue, G; Ferrari, A; Solazzo, A; Franceschini, E; Guaradi, G; Mussini, C; Cappelli, G.. - In: INTERNATIONAL JOURNAL OF STD & AIDS. - ISSN 0956-4624. - (2018), pp. 1-11. [10.1177/0956462418779659]
Alfano, G; Mori, G; Fontana, F; Dolci, G; Baisi, A; Ligabue, G; Ferrari, A; Solazzo, A; Franceschini, E; Guaradi, G; Mussini, C; Cappelli, G.
File in questo prodotto:
File Dimensione Formato  
HIV Clinical Outcome__2018.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 394.66 kB
Formato Adobe PDF
394.66 kB Adobe PDF Visualizza/Apri
VOR_Clinical outcome of kidney transplantation in HIV.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 5.02 MB
Formato Adobe PDF
5.02 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1164562
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 12
social impact