Mucormycosis is an uncommonly encountered fungal infection in solid organ transplantation. The infection is severe and often results in a fatal outcome. The most common presentations are rhino-sino-orbital and pulmonary disease. We describe a rare case of gastric mucormycosis in a patient with a combined liver-kidney transplant affected by glycogen storage disease type Ia. A 42-year-old female patient presented with gastric pain and melena 26 days after transplantation. Evaluation with upper endoscopy showed two bleeding gastric ulcers. Histological examination of gastric specimens revealed fungal hyphae with evidence of Mucormycetes at subsequent molecular analysis. Immunosuppressive therapy was reduced and antifungal therapy consisting of liposomal amphotericin B and posaconazole was promptly introduced. Gastrointestinal side effects of posaconazole and acute T-cell rejection of renal graft complicated further management of the case. A prolonged course of daily injections of amphotericin B together with a slight increase of immunosuppression favored successful treatment of mucormycosis as well as of graft rejection. After 2-year follow-up examination, the woman was found to have maintained normal renal and liver function tests. We conclude that judicious personalization of antimicrobial and antirejection therapy should be considered to resolve every life-threatening case of mucormycosis in solid organ transplantation.

Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature / Alfano, G.; Fontana, F.; Francesca, D.; Assirati, Giacomo; Magistri, P.; Tarantino, G.; Ballarin, R.; Rossi, G.; Franceschini, E.; Codeluppi, M.; Guaraldi, G.; Mussini, C.; Di Benedetto, F.; Cappelli, G.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 50:3(2018), pp. 905-909-909. [10.1016/j.transproceed.2017.11.036]

Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature

Alfano, G.
Membro del Collaboration Group
;
Fontana, F.
Membro del Collaboration Group
;
Assirati, Giacomo
Membro del Collaboration Group
;
Magistri, P.
Membro del Collaboration Group
;
Ballarin, R.
Membro del Collaboration Group
;
Franceschini, E.
Membro del Collaboration Group
;
Guaraldi, G.
Membro del Collaboration Group
;
Mussini, C.
Membro del Collaboration Group
;
Di Benedetto, F.
Membro del Collaboration Group
;
Cappelli, G.
Membro del Collaboration Group
2018

Abstract

Mucormycosis is an uncommonly encountered fungal infection in solid organ transplantation. The infection is severe and often results in a fatal outcome. The most common presentations are rhino-sino-orbital and pulmonary disease. We describe a rare case of gastric mucormycosis in a patient with a combined liver-kidney transplant affected by glycogen storage disease type Ia. A 42-year-old female patient presented with gastric pain and melena 26 days after transplantation. Evaluation with upper endoscopy showed two bleeding gastric ulcers. Histological examination of gastric specimens revealed fungal hyphae with evidence of Mucormycetes at subsequent molecular analysis. Immunosuppressive therapy was reduced and antifungal therapy consisting of liposomal amphotericin B and posaconazole was promptly introduced. Gastrointestinal side effects of posaconazole and acute T-cell rejection of renal graft complicated further management of the case. A prolonged course of daily injections of amphotericin B together with a slight increase of immunosuppression favored successful treatment of mucormycosis as well as of graft rejection. After 2-year follow-up examination, the woman was found to have maintained normal renal and liver function tests. We conclude that judicious personalization of antimicrobial and antirejection therapy should be considered to resolve every life-threatening case of mucormycosis in solid organ transplantation.
22-mar-2018
50
3
905-909
909
Gastric Mucormycosis in a Liver and Kidney Transplant Recipient: Case Report and Concise Review of Literature / Alfano, G.; Fontana, F.; Francesca, D.; Assirati, Giacomo; Magistri, P.; Tarantino, G.; Ballarin, R.; Rossi, G.; Franceschini, E.; Codeluppi, M.; Guaraldi, G.; Mussini, C.; Di Benedetto, F.; Cappelli, G.. - In: TRANSPLANTATION PROCEEDINGS. - ISSN 0041-1345. - 50:3(2018), pp. 905-909-909. [10.1016/j.transproceed.2017.11.036]
Alfano, G.; Fontana, F.; Francesca, D.; Assirati, Giacomo; Magistri, P.; Tarantino, G.; Ballarin, R.; Rossi, G.; Franceschini, E.; Codeluppi, M.; Guaraldi, G.; Mussini, C.; Di Benedetto, F.; Cappelli, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1160244
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