Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO₂-yCaO-zP₂O₅-5Ga₂O₃, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO₂-15CaO-5P₂O₅ MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium (III) / Sanchez-Salcedo, S.; Malavasi, Gianluca; Salinas, A. J.; Lusvardi, Gigliola; Rigamonti, Luca; Menabue, Ledi; Vallet-Regi, M.. - In: MATERIALS. - ISSN 1996-1944. - 11(2018), pp. 367-384.

Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium (III)

MALAVASI, Gianluca
;
LUSVARDI, Gigliola;RIGAMONTI, Luca;MENABUE, Ledi;
2018

Abstract

Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO₂-yCaO-zP₂O₅-5Ga₂O₃, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO₂-15CaO-5P₂O₅ MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.
11
367
384
Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium (III) / Sanchez-Salcedo, S.; Malavasi, Gianluca; Salinas, A. J.; Lusvardi, Gigliola; Rigamonti, Luca; Menabue, Ledi; Vallet-Regi, M.. - In: MATERIALS. - ISSN 1996-1944. - 11(2018), pp. 367-384.
Sanchez-Salcedo, S.; Malavasi, Gianluca; Salinas, A. J.; Lusvardi, Gigliola; Rigamonti, Luca; Menabue, Ledi; Vallet-Regi, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1159647
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