The sperm ultrastructure and the hypothalamo-pituitary-testicular axis, were analysed in 22 insulin-dependent diabetic men and 24 controls. GnRH was administered; subsequently FSH and LH induced-secretion was evaluated. Sperm concentration and motility were determined; TEM data were statistically evaluated with the mathematical formula of Baccetti et al. (1995). The gonadotropins response to GnRH was significantly lower in diabetics than in controls, indicating a decreased acute releasable pool of pituitary gonadotropins. In diabetic men sperm motility was significantly lower and TEM examination revealed severe structural defects, related to immaturity and apoptosis. The defective spermatogenesis may be the consequence of a direct testicular effect of the disease.
Ultrastructural sperm analysis in men with insulin-dependent diabetes / By:piomboni, P; la Marca, A; Capitani, S; Bruni, E; Gambera, L; Serafini, F; Scapigliati, G; Moretti, E; De Leo, V; Petraglia, F; Baccetti, B. - (2002), pp. 275-278. (Intervento presentato al convegno 9th International Symposium on Spermatology tenutosi a CAPE TOWN, SOUTH AFRICA nel OCT 06-11, 2002).
Ultrastructural sperm analysis in men with insulin-dependent diabetes
la Marca, A;Bruni, E;Moretti, E;Petraglia, F;
2002
Abstract
The sperm ultrastructure and the hypothalamo-pituitary-testicular axis, were analysed in 22 insulin-dependent diabetic men and 24 controls. GnRH was administered; subsequently FSH and LH induced-secretion was evaluated. Sperm concentration and motility were determined; TEM data were statistically evaluated with the mathematical formula of Baccetti et al. (1995). The gonadotropins response to GnRH was significantly lower in diabetics than in controls, indicating a decreased acute releasable pool of pituitary gonadotropins. In diabetic men sperm motility was significantly lower and TEM examination revealed severe structural defects, related to immaturity and apoptosis. The defective spermatogenesis may be the consequence of a direct testicular effect of the disease.
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