The case of a 37-year-old woman with secondary amenorrhea and clear signs of hyperandrogenism is reported. The patient underwent hormonal evaluation including circadian rhythm of cortisol, gonadotropin-releasing hormone/thyroid-stimulating hormone (GnRH/TRH) test, corticotropic-releasing hormone (CRH) test and dexamethasone suppression test. She also underwent pelvic and adrenal ultrasound examination, adrenal computed axial tomography (CAT) scan and cranial nuclear magnetic resonance (NMR). A mass about 10 cm in size was detected in the left adrenal region. The sella was empty and the pituitary displaced downward. Suspected adrenal adenocarcinoma was confirmed by histological examination after surgical removal of the mass. This case of interest for physicians because of the mixed androgen and cortisol secretion of the adenocarcinoma in a hyperprolactinemic patient with empty sella. Moreover, it suggests the need to investigate the adrenal gland in patients with hyperprolactinemia and hirsutism.

Adrenal adenocarcinoma and empty sella syndrome in a 37-year-old woman / De Leo, V.; Morgante, G.; Ditto, A.; La Marca, A.. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 13:4(1999), pp. 288-292. [10.3109/09513599909167568]

Adrenal adenocarcinoma and empty sella syndrome in a 37-year-old woman

La Marca, A.
1999-01-01

Abstract

The case of a 37-year-old woman with secondary amenorrhea and clear signs of hyperandrogenism is reported. The patient underwent hormonal evaluation including circadian rhythm of cortisol, gonadotropin-releasing hormone/thyroid-stimulating hormone (GnRH/TRH) test, corticotropic-releasing hormone (CRH) test and dexamethasone suppression test. She also underwent pelvic and adrenal ultrasound examination, adrenal computed axial tomography (CAT) scan and cranial nuclear magnetic resonance (NMR). A mass about 10 cm in size was detected in the left adrenal region. The sella was empty and the pituitary displaced downward. Suspected adrenal adenocarcinoma was confirmed by histological examination after surgical removal of the mass. This case of interest for physicians because of the mixed androgen and cortisol secretion of the adenocarcinoma in a hyperprolactinemic patient with empty sella. Moreover, it suggests the need to investigate the adrenal gland in patients with hyperprolactinemia and hirsutism.
13
4
288
292
Adrenal adenocarcinoma and empty sella syndrome in a 37-year-old woman / De Leo, V.; Morgante, G.; Ditto, A.; La Marca, A.. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 13:4(1999), pp. 288-292. [10.3109/09513599909167568]
De Leo, V.; Morgante, G.; Ditto, A.; La Marca, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1158632
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