Context: Primary ovarian insufficiency (POI) is defined as hypergonadotropic amenorrhea before the age of 40 yr. In 4-5% of patients with POI, an ovarian autoimmune process is present. Design: Serum concentrations of antimüllerian hormone (AMH) have been determined in 26 women with POI due to steroidogenic cell autoimmunity (SCA-POI), 66 with nonautoimmune idiopathic POI (iPOI), 40 postmenopausal women (PMW), and 44 healthy fertile women (HW). SCA-POI was diagnosed according to presence of steroidogenic enzyme autoantibodies (17α-hydroxylase, side chain cleavage, and 21-hydroxylase autoantibodies). Results: AMH concentrations were significantly higher in women with SCA-POI than women with iPOI (P = 0.018) orPMW(P = 0.03) but significantly lower thanHW(P < 0.0001). AMH was detected in 11 of 26 women with SCA-POI (42%) and seven of 66 with iPOI (11%) (P = 0.002). Serum concentrations above the fifth percentile of the normal range (0.6 ng/ml) were detected in nine of 26 women with SCA-POI (35%) and four of 66 with iPOI (6%) (P = 0.001). Eight of 12 women with SCA-POI with less than 5 yr (67%) and one of 14 with longer disease duration (7%) had AMH concentrations within the normal range (P = 0.003). AMH concentrations correlated inversely with disease duration in women with SCA-POI (rho = -0.563, P = 0.003) but not women with iPOI. AMH correlated inversely with FSH serum concentrations inHW(rho = -0.584, P < 0.001) but not PMW or women with POI. Conclusions: Two thirds of women with recent-onset SCA-POI had normal AMH concentrations. Women with SCA-POI, differently from those with iPOI, present a preserved ovarian follicle pool for several years after diagnosis of ovarian insufficiency. Copyright © 2009 by The Endocrine Society.

Primary ovarian insufficiency due to steroidogenic cell autoimmunity is associated with a preserved pool of functioning follicles / La Marca, Antonio; Marzotti, Stefania; Brozzetti, Annalisa; Stabile, Gaspare; Artenisio, Alfredo Carducci; Bini, Vittorio; Giordano, Roberta; De Bellis, Annamaria; Volpe, Annibale; Falorni, Alberto. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 94:10(2009), pp. 3816-3823. [10.1210/jc.2009-0817]

Primary ovarian insufficiency due to steroidogenic cell autoimmunity is associated with a preserved pool of functioning follicles

La Marca, Antonio;Volpe, Annibale;
2009

Abstract

Context: Primary ovarian insufficiency (POI) is defined as hypergonadotropic amenorrhea before the age of 40 yr. In 4-5% of patients with POI, an ovarian autoimmune process is present. Design: Serum concentrations of antimüllerian hormone (AMH) have been determined in 26 women with POI due to steroidogenic cell autoimmunity (SCA-POI), 66 with nonautoimmune idiopathic POI (iPOI), 40 postmenopausal women (PMW), and 44 healthy fertile women (HW). SCA-POI was diagnosed according to presence of steroidogenic enzyme autoantibodies (17α-hydroxylase, side chain cleavage, and 21-hydroxylase autoantibodies). Results: AMH concentrations were significantly higher in women with SCA-POI than women with iPOI (P = 0.018) orPMW(P = 0.03) but significantly lower thanHW(P < 0.0001). AMH was detected in 11 of 26 women with SCA-POI (42%) and seven of 66 with iPOI (11%) (P = 0.002). Serum concentrations above the fifth percentile of the normal range (0.6 ng/ml) were detected in nine of 26 women with SCA-POI (35%) and four of 66 with iPOI (6%) (P = 0.001). Eight of 12 women with SCA-POI with less than 5 yr (67%) and one of 14 with longer disease duration (7%) had AMH concentrations within the normal range (P = 0.003). AMH concentrations correlated inversely with disease duration in women with SCA-POI (rho = -0.563, P = 0.003) but not women with iPOI. AMH correlated inversely with FSH serum concentrations inHW(rho = -0.584, P < 0.001) but not PMW or women with POI. Conclusions: Two thirds of women with recent-onset SCA-POI had normal AMH concentrations. Women with SCA-POI, differently from those with iPOI, present a preserved ovarian follicle pool for several years after diagnosis of ovarian insufficiency. Copyright © 2009 by The Endocrine Society.
2009
94
10
3816
3823
Primary ovarian insufficiency due to steroidogenic cell autoimmunity is associated with a preserved pool of functioning follicles / La Marca, Antonio; Marzotti, Stefania; Brozzetti, Annalisa; Stabile, Gaspare; Artenisio, Alfredo Carducci; Bini, Vittorio; Giordano, Roberta; De Bellis, Annamaria; Volpe, Annibale; Falorni, Alberto. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - 94:10(2009), pp. 3816-3823. [10.1210/jc.2009-0817]
La Marca, Antonio; Marzotti, Stefania; Brozzetti, Annalisa; Stabile, Gaspare; Artenisio, Alfredo Carducci; Bini, Vittorio; Giordano, Roberta; De Bellis, Annamaria; Volpe, Annibale; Falorni, Alberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1158584
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